ArticleThe British journal of ophthalmology2006
Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study.
Article in The British journal of ophthalmology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 94 citations in OpenAlex.
- B-cell lymphoblastic lymphoma masquerading as primary dacryocystitis: A case report.Radiology case reports · 2026Article
- Clinical features and imaging findings of early lacrimal sac neoplasms: a retrospective study.Quantitative imaging in medicine and surgery · 2026Article
- Article
- Exclusive or combined endoscopic approach to tumours of the lower lacrimal pathway: review of the literature.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Review
- Ocular lymphoma: overcoming a diagnostic challenge with an endoscopic sinus approach.Irish journal of medical science · 2024Review
- Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population.International journal of ophthalmology · 2023Article
- Article
- Lacrimal sac diffuse large B-cell lymphoma: A case report.Indian journal of ophthalmology · 2022Article
- Lacrimal Sac Tumors: A Case Series.Ocular oncology and pathology · 2022Article
- Lacrimal sac lymphoma: a case report.Archives of craniofacial surgery · 2022Article
- Lacrimal sac lymphoma: a case series and literature review.International journal of ophthalmology · 2022Article
- Primary non-Hodgkin diffuse large B-cell lymphoma of the lacrimal sac: a rare case of aggressive tumor and literature review.Medicine and pharmacy reports · 2021Article
- [Masquerade lacrimal duct stenosis: prevalence of lacrimal sac tumors].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Bilateral lacrimal sac swellings in the elderly: Not always a mucocele.Indian journal of ophthalmology · 2020Article
- An Unusual Presentation of Large B-cell Lymphoma.Cureus · 2019Article
- Clinical experience on diagnosis and treatment for malignancy originating from the dacryocyst.Eye (London, England) · 2018Article
- Clinical analysis of 90 cases of malignant lacrimal sac tumor.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Chronic Lymphocytic Leukaemia/ Small-Cell Lymphocytic Lymphoma of the Lacrimal Sac: A Case Series.Ocular oncology and pathology · 2017Article
- Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature.Bosnian journal of basic medical sciences · 2017Review
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17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo define the clinical and histopathological characteristics of primary lacrimal sac lymphoma in a predominantly white population.
methodsSpecimens of lacrimal sac lymphoma and follow up data were solicited from members of the Ophthalmic Oncology Task Force of the European Organization for Research and Treatment of Cancer (EORTC) and the European Ophthalmic Pathology Society (EOPS). Specimens were stained with haematoxylin and eosin and an immunohistochemical panel against leucocyte antigens was applied. Diagnosis was reached by consensus of five experienced pathologists according to the World Health Organization classification system. The histopathological findings were correlated with the clinical data.
resultsOf 15 primary lacrimal sac lymphomas, five (33%) were diffuse large B cell lymphoma (DLBCL), five (33%) were extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma), three were classified as "transitional MALT lymphoma," being in transition from MALT lymphoma to DLBCL, and two were unclassified B cell lymphomas. Nine of the patients were female, and the median age at the time of diagnosis was 71 years (range 45-95 years). The most frequent presenting symptoms were epiphora (85%), swelling in the region of the lacrimal sac (79%), and dacryocystitis (21%). All but one patient presented in stage I. Systemic spread occurred in three of nine patients (33%). The 5 year overall survival was 65%.
conclusionsDLBCL and MALT lymphoma are equally common in the lacrimal sac in contrast with the remaining periorbital and/or orbital region where MALT lymphoma predominates.
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