ReviewClinical & experimental metastasis2005
Rat models of bone metastases.
Review in Clinical & experimental metastasis, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Animal models of cancer metastasis to the bone.Frontiers in oncology · 2023Review
- Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α-Tocopherol Acetate Supplementation.Calcified tissue international · 2022Article
- Article
- Bone-in-culture Array to Model Bone Metastasis inBio-protocol · 2020Article
- Establishment and characterization of a novel human osteosarcoma cell line for spontaneous pulmonary metastasis researchAnnals of translational medicine · 2019Article
- Monitoring bone changes due to calcium, magnesium, and phosphorus loss in rat femurs using Quantitative Ultrasound.Scientific reports · 2018Article
- Translational models of prostate cancer bone metastasis.Nature reviews. Urology · 2018Review
- Optimization andFrontiers in pharmacology · 2017Article
- The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats.Frontiers in pharmacology · 2016Review
- The influence of low-intensity physiotherapeutic ultrasound on the initial stage of bone healing in rats: an experimental and simulation study.Journal of therapeutic ultrasound · 2016Article
- Animal Models of Bone Metastasis.Veterinary pathology · 2015Review
- Article
- Validation of fluorescence molecular tomography/micro-CT multimodal imaging in vivo in rats.Molecular imaging and biology · 2014Article
- Ultrasound method applied to characterize healthy femoral diaphysis of Wistar rats in vivo.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- Rebuilding cancer metastasis in the mouse.Molecular oncology · 2013Review
- How can grafted breast cancer models be optimized?Cancer biology & therapy · 2011Review
- Three-dimensional characterization of the vascular bed in bone metastasis of the rat by microcomputed tomography (MicroCT).PloS one · 2011Article
- Article
- Logical structures extracted from metastasis experiments.Cancer science · 2009Review
- Animal models of cancer pain.Comparative medicine · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone metastases occur frequently in patients with advanced breast or prostate cancer. Bone metastases can be predominantly osteolytic, osteoblastic or mixed. Studies with animal models allow advances in understanding the molecular basis for bone metastases and provide new targets for therapy. Several animal models have been developed in rat with different pathophysiologies; they required injection or implantation of neoplastic cells into orthotopic locations, bones or the left ventricle of the heart. Several specific strains of rat have an increased incidence of spontaneous tumors. Carcinomas can be induced by either chemicals or physical agents. However, the most used and convenient way to induce bone metastases is a syngeneic transmission. MAT-Ly-Lu cells have been used in several models using Copenhagen rats to induce osteoblastic bone lesions. PA-III cells derived from Pollard tumors can also produce a combination of osteolytic and osteoblastic reactions at the site of transplantation. Osteolytic bone lesions can be obtained with an injection of Walker cells. The use of 13762 or c-SST2 cells allows also leads to osteolysis. Human xenografts can only be used in nude animals. It is essential to validate and correctly interpret the lesions in several models of bone metastasis. No animal model is sufficient by itself to represent the clinical findings observed in humans. The use of models developed in different species should be more predictive and bring a beam of arguments for a better knowledge of pathophysiological and therapeutic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.