ArticleThe Journal of clinical investigation2006
An immunologic homunculus for type 1 diabetes.
Article in The Journal of clinical investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A Single L/D-Substitution at Q4 of the mInsAFrontiers in immunology · 2021Article
- Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes.Journal of theoretical biology · 2015Article
- Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes.Journal of theoretical biology · 2015Article
- Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction.PloS one · 2011Article
- HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes.The Journal of clinical investigation · 2010Article
- Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Diabetes · 2010Article
- Primer: immunity and autoimmunity.Diabetes · 2008Article
- Conserved T cell receptor alpha-chain induces insulin autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Insulin as an autoantigen in NOD/human diabetes.Current opinion in immunology · 2008Review
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2 authors.
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Abstract
Autoimmune diseases such as the diabetes that develops in NOD mice depend on immunologic recognition of specific autoantigens, but recognition can result in a pathogenic or protective T cell response. A study by Du et al. in this issue of the JCI demonstrates that TGF-beta signaling by T cells recognizing the insulin peptide B:9-23 is essential for such protection and that this inhibitory cytokine functions in both a paracrine and an autocrine manner (see the related article beginning on page 1360). We propose that the insulin peptide B:9-23 and a conserved TCR motif form an "immunologic homunculus" underlying the relatively common targeting of insulin by T cells that, as demonstrated by the study of Du and coworkers, results in a protective T cell response, or diabetes, as shown by other investigators, for related T cell receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.