ArticleProceedings of the National Academy of Sciences of the United States of America2006
Transcription regulatory elements are punctuation marks for DNA replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- RNA polymerase II is a polar roadblock to a progressing DNA fork.Nature communications · 2025Article
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- Genome-wide mapping of spontaneous DNA replication error-hotspots using mismatch repair proteins in rapidly proliferating Escherichia coli.Nucleic acids research · 2025Article
- Article
- The in vivo measurement of replication fork velocity and pausing by lag-time analysis.Nature communications · 2023Article
- Mitogenome-wise codon usage pattern from comparative analysis of the first mitogenome of Blepharipa sp. (Muga uzifly) with other Oestroid flies.Scientific reports · 2022Article
- Transcription-replication coordination revealed in single live cells.Nucleic acids research · 2022Article
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- Article
- The roles of replication-transcription conflict in mutagenesis and evolution of genome organization.PLoS genetics · 2020Review
- Evolutionary advantage of anti-parallel strand orientation of duplex DNA.Scientific reports · 2020Article
- Transcription shapes DNA replication initiation and termination in human cells.Nature structural & molecular biology · 2019Article
- The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria.Annual review of microbiology · 2018Review
- Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms.The Journal of clinical investigation · 2018Article
- Sources of spontaneous mutagenesis in bacteria.Critical reviews in biochemistry and molecular biology · 2018Review
- A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)Cell reports · 2017Article
- Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes.Nature structural & molecular biology · 2017Article
- Review
- Article
- New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel.Biomolecules · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Collisions between DNA replication and transcription significantly affect genome organization, regulation, and stability. Previous studies have described collisions between replication forks and elongating RNA polymerases. Although replication collisions with the transcription-initiation or -termination complexes are potentially even more important because most genes are not actively transcribed during DNA replication, their existence and mechanisms remained unproven. To address this matter, we have designed a bacterial promoter that binds RNA polymerase and maintains it in the initiating mode by precluding the transition into the elongation mode. By using electrophoretic analysis of replication intermediates, we have found that this steadfast transcription-initiation complex inhibits replication fork progression in an orientation-dependent manner during head-on collisions. Transcription terminators also appeared to attenuate DNA replication, but in the opposite, codirectional orientation. Thus, transcription regulatory signals may serve as "punctuation marks" for DNA replication in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.