ArticleThorax2006
Cough frequency in children with mild asthma correlates with sputum neutrophil count.
Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 39 citations in OpenAlex.
- Neutrophilia in the bronchoalveolar lavage fluid increases coughing during flexible fiberoptic bronchoscopy in a pediatric cohort.Frontiers in pediatrics · 2024Article
- eHealth Technologies for Monitoring Pediatric Asthma at Home: Scoping Review.Journal of medical Internet research · 2023Article
- Development and technical validation of a smartphone-based pediatric cough detection algorithm.Pediatric pulmonology · 2022Article
- Th17 Lymphocytes in Children with Asthma: Do They Influence Control?Pediatric allergy, immunology, and pulmonology · 2021Article
- The objective assessment of cough frequency: accuracy of the LR102 device.Cough (London, England) · 2011Article
- A portable automatic cough analyser in the ambulatory assessment of cough.Biomedical engineering online · 2010Article
- Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma.The American journal of pathology · 2009Review
- Neutrophil airway inflammation in childhood asthma.Thorax · 2006Article
- Parent-child agreement in report of nighttime respiratory symptoms and sleep disruptions and quality.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA study was undertaken to measure cough frequency in children with stable asthma using a validated monitoring device, and to assess the correlation between cough frequency and the degree and type of airway inflammation.
methodsThirty six children of median age 11.5 years (interquartile range (IQR) 9-14) with stable asthma were recruited. They underwent spirometric testing, exhaled nitric oxide (eNO) measurement, sputum induction for differential cell count, and ambulatory cough monitoring for 24 hours. Coughing episodes were counted both as individual spikes and as clusters.
resultsAll children had mild intermittent asthma and their median forced expiratory volume in 1 second and eNO were 83.3% (IQR 81.1-97.6) and 56.1 ppb (IQR 37.4-105), respectively. The median number of cough episodes per day was 25.5 (IQR 16-42.8). Sputum induction was successful in 69% of the subjects and cough frequency was found to have a significant positive correlation with sputum neutrophil count (r = 0.833, p = 0.0001).
conclusionsChildren with stable mild asthma have increased cough frequency that might be driven by a neutrophilic inflammatory pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.