ArticleThorax2006
FEV1 decline in occupational asthma.
Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Screening tools for work-related asthma and their diagnostic accuracy: a systematic review.BMJ open respiratory research · 2025Pooled it
- What is the optimal management option for occupational asthma?European respiratory review : an official journal of the European Respiratory Society · 2012Pooled it
- Contribution of host factors and workplace exposure to the outcome of occupational asthma.European respiratory review : an official journal of the European Respiratory Society · 2012Pooled it
- Predicting the progression risk of chronic obstructive pulmonary disease in high-risk individuals based on whole-lung radiomics and deep learning: a multicenter study.Journal of thoracic disease · 2026Article
- Atopy, asthma symptoms and eosinophilic airway inflammation in British woodworkers.Occupational and environmental medicine · 2026Article
- Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease.Respiratory research · 2024Article
- Fixed Airflow Obstruction in Asthma Can Be Identified Early by Low FEF25-75% and is Associated with Environmental Exposure.Journal of asthma and allergy · 2024Article
- Among respiratory symptoms, wheeze associates most strongly with impaired lung function in adults with asthma: a long-term prospective cohort study.BMJ open respiratory research · 2021Article
- Inhalation Challenge Tests in Occupational Asthma: Why Are Multiple Tests Needed?Turkish thoracic journal · 2021Review
- Work-related asthma: A position paper from the Thoracic Society of Australia and New Zealand and the National Asthma Council Australia.Respirology (Carlton, Vic.) · 2020Review
- FEVThe World Allergy Organization journal · 2020Article
- Sputum cell counts to manage prednisone-dependent asthma: effects on FEVAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017Article
- Increased Decline in Pulmonary Function Among Employees in Norwegian Smelters Reporting Work-Related Asthma-Like Symptoms.Journal of occupational and environmental medicine · 2015Article
- Clinically relevant subgroups in COPD and asthma.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Sputum eosinophilia is a determinant of FEV1 decline in occupational asthma: results of an observational study.BMJ open · 2015Observational
- Asthma.Lancet (London, England) · 2013Review
- The persistence of allergen exposure favors pulmonary function decline in workers with allergic occupational asthma.International archives of occupational and environmental health · 2012Article
- Comparison between Airway Responses to High versus Low Molecular Weight Compounds in Occupational Asthma.Journal of allergy · 2011Article
- Asthma and rhinitis in the workplace.Current allergy and asthma reports · 2010Review
- Indoor air pollution and the health of children in biomass- and fossil-fuel users of Bangladesh: situation in two different seasons.Environmental health and preventive medicine · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn occupational asthma continued workplace exposure to the causative agent is associated with a poor prognosis. However, there is little information available on how rapidly lung function declines in those who continue to be exposed, nor how removal from exposure affects lung function.
methodsForced expiratory volume in 1 second (FEV1) was studied in 156 consecutive subjects with occupational asthma (87% due to low molecular weight agents) using simple regression analyses to provide estimates of the decline in FEV1 before and after removal from exposure.
resultsIn 90 subjects in whom FEV1 measurements had been performed for at least 1 year before removal from exposure (median 2.9 years), the mean (SE) rate of decline in FEV1 was 100.9 (17.7) ml/year. One year after removal from exposure FEV1 had improved by a mean (SE) of 12.3 (31.6) ml. The mean (SE) decline in FEV1 was 26.6 (18.0) ml/year in 86 subjects in whom measurements were made for at least 1 year (median 2.6 years) following removal from exposure. The decline in FEV1 was not significantly worse in current smokers than in never smokers, nor was it affected by the use of inhaled corticosteroids.
conclusionFEV1 declines rapidly in exposed workers with occupational asthma. Following removal from exposure, FEV1 continued to decline but at a slower rate, similar to the rate of decline in healthy adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.