ArticleBMC genomics2006
Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
- A SNP within the PMCH gene as a molecular marker associated with fertility traits in Angus and Brangus beef heifers raised under a desert environment.Tropical animal health and production · 2021Article
- Expression patterns of candidate genes reflecting the growth performance of goats subjected to heat stress.Molecular biology reports · 2018Article
- Genetic Dissection of a QTL Affecting Bone Geometry.G3 (Bethesda, Md.) · 2017Article
- Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2.BMC genomics · 2015Article
- Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.PloS one · 2015Article
- Validation of simple sequence length polymorphism regions of commonly used mouse strains for marker assisted speed congenics screening.International journal of genomics · 2015Article
- Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene.Physiological genomics · 2013Article
- QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.PloS one · 2013Article
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Article
- Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.Physiological genomics · 2009Article
- Evidence of maternal QTL affecting growth and obesity in adult mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice.Genes, brain, and behavior · 2008Article
- Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.BMC genetics · 2008Article
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Dissection of a genetically complex cluster of growth and obesity QTLs on mouse chromosome 2 using subcongenic intercrosses.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Article
- Segregation analysis of a sex ratio distortion locus in congenic mice.The Journal of heredityArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh growth (hg) modifier and background independent quantitative trait loci (QTL) affecting growth, adiposity and carcass composition were previously identified on mouse chromosomes (MMU) 1, 2, 5, 8, 9, 11 and 17. To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds.
resultsThe first speed congenic panel was developed by introgressing four overlapping donor regions spanning MMU2 in its entirety onto both HG and B6 backgrounds, for a total of eight strains. Phenotypic characterization of the MMU2 panel confirmed the segregation of multiple growth and obesity QTL and strongly suggested that a subset of these loci modify the effects of the hg deletion. The second panel consisted of individual donor regions on an HG background for each QTL on MMU1, 5, 8, 9, 11 and 17. Of the six developed strains, five were successfully characterized and displayed significant differences in growth and/or obesity as compared to controls. All five displayed phenotypes similar to those originally attributed to each QTL, however, novel phenotypes were unmasked in several of the strains including sex-specific effects.
conclusionThe speed congenic strains developed herein constitute an invaluable genomic resource and provide the foundation to identify the specific nature of genetic variation influencing growth and obesity.
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