ArticleBMC infectious diseases2006
Candidaemia and antifungal therapy in a French University Hospital: rough trends over a decade and possible links.
Article in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Activity ofVirulence · 2026Article
- Biofilm formation and increased mortality among cancer patients with candidemia in a Peruvian reference center.BMC infectious diseases · 2024Article
- Impact of antifungal stewardship interventions on the susceptibility of colonized Candida species in pediatric patients with malignancy.Scientific reports · 2021Article
- A Pilot Clinical Study on Post-Operative Recurrence Provides Biological Clues for a Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- Epidemiology of Candida albicans and non-C.albicans of neonatal candidemia at a tertiary care hospital in western China.BMC infectious diseases · 2017Article
- Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model.Pharmaceutical research · 2017Article
- Temporal Trends in Blood Stream Infection Isolates from Surgical Patients.Surgical infections · 2015Article
- Management of invasive candidiasis in nonneutropenic ICU patients.Therapeutic advances in infectious disease · 2014Review
- Usefulness of defined daily dose and days of therapy in pediatrics and obstetrics-gynecology: a comparative analysis of antifungal drugs (2000-2001, 2005-2006, and 2010-2011).The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2014Article
- Non-albicans Candida species in blood stream infections in a tertiary care hospital at New Delhi, India.The Indian journal of medical research · 2012Article
- Mannose-binding lectin levels and variation during invasive candidiasis.Journal of clinical immunology · 2012Article
- Article
- Hospital epidemiology and infection control in acute-care settings.Clinical microbiology reviews · 2011Review
- National surveillance of fungemia in Denmark (2004 to 2009).Journal of clinical microbiology · 2011Article
- Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007.Journal of clinical microbiology · 2009Article
- Multidisciplinary approach to the treatment of invasive fungal infections in adult patients. Prophylaxis, empirical, preemptive or targeted therapy, which is the best in the different hosts?Therapeutics and clinical risk management · 2008Article
- Significant alterations in the epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies.International journal of hematology · 2008Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence for an increased prevalence of candidaemia and for high associated mortality in the 1990s led to a number of different recommendations concerning the management of at risk patients as well as an increase in the availability and prescription of new antifungal agents. The aim of this study was to parallel in our hospital candidemia incidence with the nature of prescribed antifungal drugs between 1993 and 2003.
methodsDuring this 10-year period we reviewed all cases of candidemia, and collected all the data about annual consumption of prescribed antifungal drugs.
resultsOur centralised clinical mycology laboratory isolates and identifies all yeasts grown from blood cultures obtained from a 3300 bed teaching hospital. Between 1993 and 2003, 430 blood yeast isolates were identified. Examination of the trends in isolation revealed a clear decrease in number of yeast isolates recovered between 1995-2000, whereas the number of positive blood cultures in 2003 rose to 1993 levels. The relative prevalence of Candida albicans and C. glabrata was similar in 1993 and 2003 in contrast to the period 1995-2000 where an increased prevalence of C. glabrata was observed. When these quantitative and qualitative data were compared to the amount and type of antifungal agents prescribed during the same period (annual mean defined daily dose: 2662741; annual mean cost: 615,629 euros) a single correlation was found between the decrease in number of yeast isolates, the increased prevalence of C. glabrata and the high level of prescription of fluconazole at prophylactic doses between 1995-2000.
conclusionBetween 1993 and 2000, the number of cases of candidemia halved, with an increase of C. glabrata prevalence. These findings were probably linked to the use of Fluconazole prophylaxis. Although it is not possible to make any recommendations from this data the information is nevertheless interesting and may have considerable implications with the introduction of new antifungal drugs.
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