ArticlePlant physiology1992
Cloning and Characterization of an Arabidopsis thaliana Topoisomerase I Gene.
Article in Plant physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants.Journal of advanced research · 2025Review
- The Emerging Role of the Salt Tolerance-Related Protein in the Abiotic Stress Response ofPlants (Basel, Switzerland) · 2025Review
- Joseph J. Kieber.The Plant cell · 2018Article
- Epigenetic Mechanisms Are Critical for the Regulation of WUSCHEL Expression in Floral Meristems.Plant physiology · 2015Review
- A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis.The Plant cell · 2014Article
- DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis.The Plant cell · 2014Article
- MGOUN1 encodes an Arabidopsis type IB DNA topoisomerase required in stem cell regulation and to maintain developmentally regulated gene silencing.The Plant cell · 2010Article
- Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition.The Biochemical journal · 2008Article
- Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Pea DNA topoisomerase I is phosphorylated and stimulated by casein kinase 2 and protein kinase C.Plant physiology · 2003Article
- Disruption of a DNA topoisomerase I gene affects morphogenesis in Arabidopsis.The Plant cell · 2002Article
- Cloning, expression and characterization of a gene which encodes a topoisomerase I with positive supercoiling activity in pea.Plant molecular biology · 1998Article
- Thi1, a thiamine biosynthetic gene in Arabidopsis thaliana, complements bacterial defects in DNA repair.Plant molecular biology · 1996Article
- Repair of DNA damage induced by ultraviolet radiation.Plant physiology · 1995Review
- Purification and characterization of a DNA strand transferase from broccoli.Plant physiology · 1995Article
- Cloning of a 3-methyladenine-DNA glycosylase from Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.Genetics · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cDNA and genomic clones encoding DNA topoisomerase I were isolated from Arabidopsis thaliana lambdagt11 and lambdaFix libraries by low stringency hybridization with a Saccharomyces cerevisiae TOP1 probe. The cDNA clones include a 2748-base pair open reading frame predicting an amino acid sequence that is highly homologous to sequences encoded by TOP1 from yeast and human sources. The sequence of the upstream genomic region reveals two putative TATA-like elements and a purine-rich region, but no other obvious controlling elements. Southern blot analysis shows that the gene is present as a single copy in the Arabidopsis genome. When expressed in a S. cerevisiae top1 mutant under the control of the GAL1 promoter, the gene complements the phenotype caused by loss of topoisomerase activity and directs the expression of a protein that cross-reacts with a human anti-topoisomerase I antibody.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.