ArticleMammalian genome : official journal of the International Mammalian Genome Society1991
Pleiotropic action of the murine quaking locus: structure of the qkv allele.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- A new spontaneous deletion on chromosome 17 including brachyury.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Detailed physical and genetic mapping in the region of plasminogen, D17Rp17e, and quaking.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- The proximal end of mouse chromosome 17: new molecular markers identify a deletion associated with quakingviable.Genetics · 1992Article
- Mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Meiotic mapping of murine chromosome 17: the string of loci around l(17)-2Pas.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The spontaneous allele quakingviable (qkv) exerts effects on myelination and spermiogenesis. The defects generated by qkv were not separated in a multilocus mapping cross that provided a mapping resolution of 0.1 centiMorgans (cM). Furthermore, no distortions suggestive of a large chromosomal anomaly associated with qkv were apparent. One plausible interpretation is that the quaking locus contains more than one functional domain, either organized into overlapping genes or expressed by alternative splicing mechanisms. The cloning needed to analyze this locus will be enhanced by the very high resolution of the meiotic mapping cross reported here. The recombinational distances on this qkv map were compressed compared with those previously reported in a high-resolution map for qkl-1, an embryonic lethal allele of quaking induced by ethylnitrosourea. Additional crosses confirmed prior reports that the sex and the genetic background of the heterozygous parent can affect recombinational distances. These joint effects on recombination are strong enough to account for the discrepancy between the two maps. This variability of two-factor map values leads to the preferred multilocus map-building protocol discussed in the accompanying paper.
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Registered trials
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