ArticlePlant physiology1992
Modulation of Na/H Antiporter Activity by Extreme pH and Salt in the Halotolerant Alga Dunaliella salina.
Article in Plant physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 38 citations in OpenAlex.
- Cross-domain transfer of trehalose biosynthesis genes contributes to adaptation in high-altitude environments.National science review · 2026Article
- Article
- Adaptations to High Salt in a Halophilic Protist: Differential Expression and Gene Acquisitions through Duplications and Gene Transfers.Frontiers in microbiology · 2017Article
- Bioenergetic aspects of halophilism.Microbiology and molecular biology reviews : MMBR · 1999Review
- Ion Homeostasis in NaCl Stress Environments.Plant physiology · 1995Article
- Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells.Journal of bioenergetics and biomembranes · 1993Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of different growth conditions on the activity of the Na(+)/H(+) antiporter in Dunaliella salina has been investigated. Adaptation of D. salina cells to ammonia at alkaline pH or to high NaCl concentrations is associated with a pronounced increase in the plasma membrane Na(+)/H(+) exchange activity. The enhanced activity is manifested both in vivo, by stimulation of Na(+) influx into intact cells in response to internal acidification, and in vitro, by a larger (22)Na accumulation in plasma membrane vesicles in response to an induced pH gradient. Kinetic analysis shows that the stimulation does not result from a change of the K(m) for Na(+) but from an increase in the V(max). In contrast, adaptation of cells to a high LiCl concentration (0.8 m) depresses the activity of the Na(+)/H(+) antiporter. Adaptation to ammonia is also associated with a large increase of three polypeptide bands in purified plasma membrane preparations, indicating that they may compose the antiporter polypeptides. These results suggest that adaptation to ammonia or to high salinity induces overproduction of the plasma membrane Na(+)/H(+) antiporter in Dunaliella.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.