ArticleOncogene2006
DNA-binding independent cell death from a minimal proapoptotic region of E2F-1.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- E2F-1-Akt1 Interaction as Precursor to Cisplatin-induced Apoptosis in Triple-negative Breast Cancer Cells.Oman medical journal · 2025Article
- Mechanistic Insights about Sorafenib-, Valproic Acid- and Metformin-Induced Cell Death in Hepatocellular Carcinoma.International journal of molecular sciences · 2024Review
- DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions.The FEBS journal · 2022Article
- The broken cycle: E2F dysfunction in cancer.Nature reviews. Cancer · 2019Review
- NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.EMBO reports · 2018Article
- Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks.PloS one · 2018Article
- DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose.Cell death and differentiation · 2015Article
- Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?Cell death & disease · 2014Review
- Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.PLoS computational biology · 2014Article
- Enhanced cancer cell killing by truncated E2F-1 used in combination with oncolytic adenovirus.Virology · 2012Article
- Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- E2F-1- and E2Ftr-mediated apoptosis: the role of DREAM and HRK.Journal of cellular and molecular medicine · 2012Article
- DRAM-1 encodes multiple isoforms that regulate autophagy.Autophagy · 2012Article
- Adenovirus-mediated expression of truncated E2F-1 suppresses tumor growth in vitro and in vivo.Cancer · 2010Article
- Phosphorylation of Puma modulates its apoptotic function by regulating protein stability.Cell death & disease · 2010Article
- Oncogene-induced sensitization to chemotherapy-induced death requires induction as well as deregulation of E2F1.Cancer research · 2010Article
- Article
- Cytoplasmic initiation of cisplatin cytotoxicity.American journal of physiology. Renal physiology · 2008Article
- Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy.Journal of virology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to induce cell cycle progression while evading cell death is a defining characteristic of cancer. Deregulation of E2F is a common event in most human cancers. Paradoxically, this can lead to both cell cycle progression and apoptosis. Although the way in which E2F causes cell cycle progression is well characterized, the pathways by which E2F induces cell death are less well defined. Many of the known mechanisms through which E2F induces apoptosis occur through regulation of E2F target genes. However, mutants of E2F-1 that lack the transactivation domain are still able to induce cell death. To further investigate this activity, we refined a transactivation independent mutant to identify a minimal apoptotic domain. This revealed that only 75 amino acids from within the DNA-binding domain of E2F-1 is sufficient for cell death and that this activity is also present in the DNA-binding domains of E2F-2 and E2F-3. However, analysis of this domain from E2F-1 revealed it does not bind DNA and is consequently unable to transactivate, repress or de-repress E2F target genes. This provocative observation therefore defines a potential new mechanism of death from E2F and opens up new opportunities for inducing cell death in tumours for therapeutic gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.