ArticleProstate cancer and prostatic diseases2006
Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.
Article in Prostate cancer and prostatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Targeting the tumor microenvironment, a new therapeutic approach for prostate cancer.Prostate cancer and prostatic diseases · 2025Review
- The Potential of Extracellular Matrix- and Integrin Adhesion Complex-Related Molecules for Prostate Cancer Biomarker Discovery.Biomedicines · 2023Review
- Potential of the Stromal Matricellular Protein Periostin as a Biomarker to Improve Risk Assessment in Prostate Cancer.International journal of molecular sciences · 2022Article
- Non-Coding RNAs Set a New Phenotypic Frontier in Prostate Cancer Metastasis and Resistance.International journal of molecular sciences · 2021Review
- Review
- Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance.Cold Spring Harbor perspectives in medicine · 2018Review
- High Grade T1 Papillary Urothelial Bladder Cancer Shows Prominent Peritumoral Retraction Clefting.Pathology oncology research : POR · 2018Article
- Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes.Oncotarget · 2016Article
- Expression analysis of α-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture.International journal of oral science · 2015Article
- Prostate cancer stroma: an important factor in cancer growth and progression.Bosnian journal of basic medical sciences · 2015Review
- Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma.Pathology oncology research : POR · 2012Article
- Periacinar retraction clefting in nonneoplastic and neoplastic prostatic glands: artifact or molecular involvement.Pathology oncology research : POR · 2012Article
- Peritumoral retraction clefting correlates with advanced stage squamous cell carcinoma of the esophagus.Pathology oncology research : POR · 2008Article
- Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis.Cancer research · 2008Article
- Periacinar retraction clefting in proliferative prostatic atrophy and prostatic adenocarcinoma.Journal of clinical pathology · 2007Article
- Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation.Molecular and cellular pharmacologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.
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Registered trials
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