ArticleThe American journal of pathology2006
Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Protein Kinase CK2-A Putative Target for the Therapy of Diabetes Mellitus?International journal of molecular sciences · 2019Review
- Diabetic complications in the cornea.Vision research · 2017Review
- Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model.BMC ophthalmology · 2017Article
- Stem cell therapies in the treatment of diabetic retinopathy and keratopathy.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.Journal of neuroinflammation · 2016Article
- Cell rounding in cultured human astrocytes and vascular endothelial cells upon inhibition of CK2 is mediated by actomyosin cytoskeleton alterations.Journal of cellular biochemistry · 2012Article
- Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways.Leukemia · 2012Review
- Article
- Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model.Investigative ophthalmology & visual science · 2011Article
- Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury.The American journal of pathology · 2011Article
- Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton.Molecular and cellular biochemistry · 2011Article
- Protein kinase CK2 and new binding partners during spermatogenesis.Cellular and molecular life sciences : CMLS · 2010Article
- Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene.Investigative ophthalmology & visual science · 2010Article
- Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes.Brain research bulletin · 2010Article
- The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model.Documenta ophthalmologica. Advances in ophthalmology · 2010Review
- Erratum: Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.Journal of ocular biology, diseases, and informatics · 2009Article
- ZBED4, a BED-type zinc-finger protein in the cones of the human retina.Investigative ophthalmology & visual science · 2009Article
- Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.Journal of ocular biology, diseases, and informatics · 2009Article
- FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats.Diabetes · 2009Article
- Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites.Molecular and cellular biochemistry · 2008Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
We previously documented protein kinase CK2 involvement in retinal neovascularization. Here we describe retinal CK2 expression and combined effects of CK2 inhibitors with the somatostatin analog octreotide in a mouse model of oxygen-induced retinopathy (OIR). CK2 expression in human and rodent retinas with and without retinopathy and in astrocytic and endothelial cultures was examined by immunohistochemistry, Western blotting, and reverse transcriptase-polymerase chain reaction. A combination of CK2 inhibitors, emodin or 4,5,6,7-tetrabromobenzotriazole, with octreotide was injected intraperitoneally from postnatal (P) day P11 to P17 to block mouse OIR. All CK2 subunits (alpha, alpha', beta) were expressed in retina, and a novel CK2alpha splice variant was detected by reverse transcriptase-polymerase chain reaction. CK2 antibodies primarily reacted with retinal astrocytes, and staining was increased around new intraretinal vessels in mouse OIR and rat retinopathy of prematurity, whereas preretinal vessels were negative. Cultured astrocytes showed increased perinuclear CK2 staining compared to endothelial cells. In the OIR model, CK2 mRNA expression increased modestly on P13 but not on P17. Octreotide combined with emodin or 4,5,6,7-tetrabromobenzotriazole blocked mouse retinal neovascularization more efficiently than either compound alone. Based on its retinal localization, CK2 may be considered a new immunohistochemical astrocytic marker, and combination of CK2 inhibitors and octreotide may be a promising future treatment for proliferative retinopathies.
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