ArticleThe American journal of pathology2006
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS).International immunology · 2023Review
- Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?International journal of molecular sciences · 2020Review
- Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12.Cancers · 2019Review
- A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage.PloS one · 2019Article
- Osteopontin facilitates West Nile virus neuroinvasion via neutrophil "Trojan horse" transport.Scientific reports · 2017Article
- Functional assessment of glioma pathogenesis by in vivo multi-parametric magnetic resonance imaging and in vitro analyses.Scientific reports · 2016Article
- Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells.Journal of neuroimmunology · 2015Article
- Promoted Growth of Brain Tumor by the Transplantation of Neural Stem/Progenitor Cells Facilitated by CXCL12.Translational oncology · 2014Article
- Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.British journal of cancer · 2014Article
- Vasculogenesis: a crucial player in the resistance of solid tumours to radiotherapy.The British journal of radiology · 2014Review
- Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats.Neuro-oncology · 2014Article
- Inhibiting vasculogenesis after radiation: a new paradigm to improve local control by radiotherapy.Seminars in radiation oncology · 2013Review
- Hypoxia-related molecules HIF-1α, CA9, and osteopontin : predictors of survival in patients with high-grade glioma.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013Article
- Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model.PloS one · 2012Article
- 5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.International journal of cancer · 2011Article
- Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma.Immunology · 2011Article
- Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells.Neuro-oncology · 2010Article
- Involvement of osteopontin as a core protein in craniopharyngioma calcification formation.Journal of neuro-oncology · 2010Article
- Osteopontin regulates human glioma cell invasiveness and tumor growth in mice.Neuro-oncology · 2010Article
- Wnt/beta-catenin/Tcf signaling pathway activation in malignant progression of rat gliomas induced by transplacental N-ethyl-N-nitrosourea exposure.Neurochemical research · 2009Article
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11 authors at 3 institutions in 1 country.
Funding
Abstract
To better study early events in glioma genesis, markers that reliably denote landmarks in glioma development are needed. In the present study, we used microarray analysis to compare the gene expression patterns of magnetic resonance imaging (MRI)-localized N-ethyl-N-nitrosourea (ENU)-induced tumors in rat brains with those of uninvolved contralateral side and normal brains. Our analysis identified osteopontin (OPN) as the most up-regulated gene in glioma. Using immunohistochemistry we then confirmed OPN expression in every tumor examined (n = 17), including those with diameters as small as 300 mum. By contrast, no OPN immunostaining was seen in normal brain or in brains removed from ENU-exposed rats before the development of glioma. Further studies confirmed that OPN was co-localized exclusively in intratumoral glial fibrillary acidic protein-expressing cells and was notably absent from nestin-expressing ones. In conjunction with this, we confirmed that both normal neurosphere cells and ENU-im-mortalized subventricular zone/striatal cells produced negligible amounts of OPN compared to the established rat glioma cell line C6. Furthermore, inducing OPN expression in an immortalized cell line increased cell proliferation. Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression.
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