ArticleThe American journal of pathology2006
Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 0 citations in OpenAlex.
- Opioid abuse and SIV infection in non-human primates.Journal of neurovirology · 2023Review
- Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS.Pathogens (Basel, Switzerland) · 2021Review
- Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques.Journal of virology · 2020Article
- No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications.Archives of virology · 2019Article
- A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.PLoS pathogens · 2017Article
- Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND).Current HIV/AIDS reports · 2015Review
- Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.Journal of virology · 2014Article
- Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency virus model of encephalitis.Journal of virology · 2014Article
- Increased toll-like receptor signaling pathways characterize CD8+ cells in rapidly progressive SIV infection.BioMed research international · 2013Article
- Proteomic biosignatures for monocyte-macrophage differentiation.Cellular immunology · 2011Article
- Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood-brain barrier and infection by HIV: implications for NeuroAIDS.Cellular immunology · 2011Article
- Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.The American journal of pathology · 2010Article
- Ex vivo analysis of SIV-infected cells by flow cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2010Article
- Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques.The American journal of pathology · 2010Article
- Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage.Journal of leukocyte biology · 2010Article
- CD4 deficits and disease course acceleration can be driven by a collapse of the CD8 response in rhesus macaques infected with simian immunodeficiency virus.AIDS (London, England) · 2008Article
- YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor.The American journal of pathology · 2008Article
- YKL-40: a candidate biomarker for simian immunodeficiency virus and human immunodeficiency virus encephalitis?The American journal of pathology · 2008Review
- Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration.The American journal of pathology · 2008Article
- Increased expression of monocyte CD44v6 correlates with the deveopment of encephalitis in rhesus macaques infected with simian immunodeficiency virus.The Journal of infectious diseases · 2008Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The histopathological hallmark of lentiviral-associated encephalitis is an abundance of infected and activated macrophages. Why a subset of infected hosts develops lentiviral encephalitis and others do not is unknown. Using a CD8(+) T-cell depletion model of simian immunodeficiency virus (SIV)-infected rhesus macaques, we examined the relationship between peripheral SIV infection of monocytes/macrophages and the development of encephalitis. At the same time that cerebral spinal fluid viral load increased in macaques that developed encephalitis, we observed that monocyte-derived macrophages from these macaques produced more virus than those from macaques that did not develop encephalitis. However, during the course of infection, the number of blood monocyte-associated SIV DNA copies did not distinguish macaques that developed simian immunodeficiency virus encephalitis from macaques that did not develop encephalitis. Paradoxically, in this model, macaques that developed encephalitis had fewer SIV-infected macrophages in lungs and thymus at postmortem than macaques that did not develop encephalitis. These findings suggest that inherent differences in host monocyte viral production are related to development of encephalitis.
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