ArticleHearing research
Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus.
Article in Hearing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurometric amplitude modulation detection in the inferior colliculus of Young and Aged rats.Hearing research · 2024Article
- Effects of the two-pore potassium channel subunit Task5 on neuronal function and signal processing in the auditory brainstem.Frontiers in cellular neuroscience · 2024Article
- Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modulation of Neuronal Potassium Channels During Auditory Processing.Frontiers in neuroscience · 2021Review
- Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation.Brain sciences · 2020Article
- Attenuation of noise-induced hyperactivity in the dorsal cochlear nucleus by pre-treatment with MK-801.Brain research · 2018Article
- Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.The Journal of biological chemistry · 2014Article
- Modulation of gene expression in guinea pig paraflocculus after induction of hearing loss.F1000Research · 2014Article
- Suppression of spikes during posttetanic hyperpolarization in auditory neurons: the role of temperature, I(h) currents, and the Na(+)-K(+)-ATPase pump.Journal of neurophysiology · 2012Article
- Mechanisms contributing to central excitability changes during hearing loss.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Cortical Auditory Deafferentation Induces Long-Term Plasticity in the Inferior Colliculus of Adult Rats: Microarray and qPCR Analysis.Frontiers in neural circuits · 2012Article
- Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Tinnitus: Models and mechanisms.Hearing research · 2011Review
- Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.Neuroscience · 2011Article
- Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.Neuroscience · 2007Article
- Potassium channel gene expression in the rat cochlear nucleus.Hearing research · 2007Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Two-pore domain potassium channels (K(2PD)+) play an important role in setting resting membrane potential by regulating background leakage of potassium ions, which in turn controls neuronal excitability. To determine whether these channels contribute to activity-dependent plasticity following deafness, we used quantitative real-time PCR to examine the expression of 10 K(2PD)+ subunits in the rat cochlear nucleus at 3 days, 3 weeks and 3 months after bilateral cochlear ablation. There was a large sustained decrease in the expression of TASK-5, a subunit that is predominantly expressed in auditory brain stem neurons, and in the TASK-1 subunit which is highly expressed in several types of cochlear nucleus neurons. TWIK-1 and THIK-2 also showed significant decreases in expression that were maintained across all time points. TWIK-2, TREK-1 and TREK-2 showed no significant change in expression at 3 days but showed large decreases at 3 weeks and 3 months following deafness. TRAAK and TASK-3 subunits showed significant decreases at 3 days and 3 weeks following deafness, but these differences were no longer significant at 3 months. Dramatic changes in expression of K(2PD)+ subunits suggest these channels may play a role in deafness-associated changes in the excitability of cochlear nucleus neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.