ArticleJournal of computational neuroscience2006
Spike propagation in dendrites with stochastic ion channels.
Article in Journal of computational neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- A universal workflow for creation, validation, and generalization of detailed neuronal models.Patterns (New York, N.Y.) · 2023Article
- Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.Science advances · 2023Article
- Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo.Nature communications · 2022Article
- Cortical reliability amid noise and chaos.Nature communications · 2019Article
- Patterned Brain Stimulation, What a Framework with Rhythmic and Noisy Components Might Tell Us about Recovery Maximization.Frontiers in human neuroscience · 2013Article
- The effect of neural noise on spike time precision in a detailed CA3 neuron model.Computational and mathematical methods in medicine · 2012Article
- Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes.PLoS computational biology · 2010Article
- Stochastically gating ion channels enable patterned spike firing through activity-dependent modulation of spike probability.PLoS computational biology · 2009Article
- Stochastic simulations on the reliability of action potential propagation in thin axons.PLoS computational biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the effects of the stochastic nature of ion channels on the faithfulness, precision and reproducibility of electrical signal transmission in weakly active, dendritic membrane under in vitro conditions. The properties of forward and backpropagating action potentials (BPAPs) in the dendritic tree of pyramidal cells are the subject of intense empirical work and theoretical speculation (Larkum et al., 1999; Zhu, 2000; Larkum et al., 2001; Larkum and Zhu, 2002; Schaefer et al., 2003; Williams, 2004; Waters et al., 2005). We numerically simulate the effects of stochastic ion channels on the forward and backward propagation of dendritic spikes in Monte-Carlo simulations on a reconstructed layer 5 pyramidal neuron. We report that in most instances there is little variation in timing or amplitude for a single BPAP, while variable backpropagation can occur for trains of action potentials. Additionally, we find that the generation and forward propagation of dendritic Ca(2+) spikes are susceptible to channel variability. This indicates limitations on computations that depend on the precise timing of Ca(2+) spikes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.