ArticleThe Journal of membrane biology2005
Epithelial fluid transport: protruding macromolecules and space charges can bring about electro-osmotic coupling at the tight junctions.
Article in The Journal of membrane biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- A mathematical model of corneal endothelium pump function.Journal of the Royal Society, Interface · 2025Article
- Article
- Net Fluorescein Flux Across Corneal Endothelium Strongly Suggests Fluid Transport is due to Electro-osmosis.The Journal of membrane biology · 2016Article
- Transient swelling, spreading, and drug delivery by a dissolved anti-HIV microbicide-bearing film.Physics of fluids (Woodbury, N.Y. : 1994) · 2013Article
- Osmoregulation and epithelial water transport: lessons from the intestine of marine teleost fish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Review
- Comparative permeabilities of the paracellular and transcellular pathways of corneal endothelial layers.The Journal of membrane biology · 2011Article
- Frequency spectrum of transepithelial potential difference reveals transport-related oscillations.Biophysical journal · 2009Article
- Determination of zeta-potential in rat organotypic hippocampal cultures.Biophysical journal · 2008Article
- Fluid transport: a guide for the perplexed.The Journal of membrane biology · 2008Review
- Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium.Experimental eye research · 2007Article
- The Role of the Tight Junction in Paracellular Fluid Transport across Corneal Endothelium. Electro-osmosis as a Driving Force.The Journal of membrane biology · 2006Review
- Na+ recirculation and isosmotic transport.The Journal of membrane biology · 2006Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The purpose of the present work is to investigate whether the idea of epithelial fluid transport based on electro-osmotic coupling at the level of the leaky tight junction (TJ) can be further supported by a plausible theoretical model. We develop a model for fluid transport across epithelial layers based on electro-osmotic coupling at leaky tight junctions (TJ) possessing protruding macromolecules and fixed electrical charges. The model embodies systems of electro-hydrodynamic equations for the intercellular pathway, namely the Brinkman and the Poisson-Boltzmann differential equations applied to the TJ. We obtain analytical solutions for a system of these two equations, and are able to derive expressions for the fluid velocity profile and the electrostatic potential. We illustrate the model by employing geometrical parameters and experimental data from the corneal endothelium, for which we have previously reported evidence for a central role for electro-osmosis in translayer fluid transport. Our results suggest that electro-osmotic coupling at the TJ can account for fluid transport by the corneal endothelium. We conclude that electro-osmotic coupling at the tight junctions could represent one of the basic mechanisms driving fluid transport across some leaky epithelia, a process that remains unexplained.
Indexed as
Identifiers
16648941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.