ArticleEMBO reports2006
Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons.
Article in EMBO reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer.Nature communications · 2024Article
- Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhibiting Notch Signalling.Molecular neurobiology · 2022Article
- Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.Journal of molecular biology · 2018Article
- An oncologist׳s friend: How Xenopus contributes to cancer research.Developmental biology · 2015Review
- Multi-site phospho-regulation of proneural transcription factors controls proliferation versus differentiation in development and reprogramming.Neurogenesis (Austin, Tex.) · 2015Article
- Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation.Cell division · 2013Article
- Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders.Genes to cells : devoted to molecular & cellular mechanisms · 2013Review
- How to keep proliferative neural stem/progenitor cells: a critical role of asymmetric inheritance of cyclin D2.Cell cycle (Georgetown, Tex.) · 2012Article
- Non-genetic modulation of Notch activity by artificial delivery of Notch intracellular domain into neural stem cells.Stem cell reviews and reports · 2012Article
- Co-ordination of cell cycle and differentiation in the developing nervous system.The Biochemical journal · 2012Review
- The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.Cell cycle (Georgetown, Tex.) · 2011Article
- Article
- Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.Developmental cell · 2010Article
- Article
- Zebrafish Rohon-Beard neuron development: cdk5 in the midst.Neurochemical research · 2009Review
- Antidepressants and Cdk inhibitors: releasing the brake on neurogenesis?Cell cycle (Georgetown, Tex.) · 2008Review
- The Xenopus cell cycle: an overview.Molecular biotechnology · 2008Review
- The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle.Neural development · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The proneural protein neurogenin (XNGNR1) drives differentiation of primary neurons in combination with the cyclin-dependent kinase (Cdk) inhibitor Xic1. Differentiation is inhibited by Notch signalling, resulting in a scattered neuronal distribution. Here we show that Notch signalling regulates the level of Xic1 transcription, yet this does not correlate with Notch's ability to perturb the cell cycle. Instead, Notch may regulate Xic1 levels to control its differentiation function directly, which is required in parallel with XNGNR1 to promote primary neurogenesis. Indeed, Notch-mediated repression of both XNGNR1 and Xic1 must be relieved for neuronal differentiation to occur. Interestingly, although Xic1 is required for XNGNR1-mediated neurogenesis, it is not required for XNGNR1-mediated upregulation of Delta, allowing establishment of the negative feedback loop involved in lateral inhibition. Therefore, Notch targets Cdk inhibitor expression to regulate differentiation of primary neurons, and its effects on the cell cycle may be of secondary importance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.