ArticleGenetics2006
Unusual DNA structures associated with germline genetic activity in Caenorhabditis elegans.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Parameters that influence bipartite reporter system expression in Caenorhabditis elegans.Genetics · 2025Article
- Article
- Deciphering the mechanical code of the genome and epigenome.Nature structural & molecular biology · 2022Article
- Nematode chromosomes.Genetics · 2022Review
- Human Virus Genomes Are Enriched in Conserved Adenine/Thymine/Uracil Multiple Tracts That Pause Polymerase Progression.Frontiers in microbiology · 2022Article
- High-efficiency CRISPR gene editing in C. elegans using Cas9 integrated into the genome.PLoS genetics · 2021Article
- Double-stranded RNA bending by AU-tract sequences.Nucleic acids research · 2020Article
- Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans.Nature communications · 2020Article
- Distinctive regulatory architectures of germline-active and somatic genes inGenome research · 2020Article
- Understanding the paradoxical mechanical response of in-phase A-tracts at different force regimes.Nucleic acids research · 2020Article
- Multigenerational Regulation of theAnnual review of genetics · 2019Review
- TheGenetics · 2019Review
- Assessment and Maintenance of Unigametic Germline Inheritance for C. elegans.Developmental cell · 2019Article
- Intergenerational and transgenerational epigenetic inheritance in animals.Nature cell biology · 2019Review
- The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes.Science (New York, N.Y.) · 2018Article
- Article
- A streamlined tethered chromosome conformation capture protocol.BMC genomics · 2016Article
- Reproducible features of small RNAs in C. elegans reveal NU RNAs and provide insights into 22G RNAs and 26G RNAs.RNA (New York, N.Y.) · 2016Article
- Comparative RNA-Seq analysis reveals pervasive tissue-specific alternative polyadenylation in Caenorhabditis elegans intestine and muscles.BMC biology · 2015Article
- Unusual DNA packaging characteristics in endoreduplicated Caenorhabditis elegans oocytes defined by in vivo accessibility to an endogenous nuclease activity.Epigenetics & chromatin · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We describe a surprising long-range periodicity that underlies a substantial fraction of C. elegans genomic sequence. Extended segments (up to several hundred nucleotides) of the C. elegans genome show a strong bias toward occurrence of AA/TT dinucleotides along one face of the helix while little or no such constraint is evident on the opposite helical face. Segments with this characteristic periodicity are highly overrepresented in intron sequences and are associated with a large fraction of genes with known germline expression in C. elegans. In addition to altering the path and flexibility of DNA in vitro, sequences of this character have been shown by others to constrain DNA::nucleosome interactions, potentially producing a structure that could resist the assembly of highly ordered (phased) nucleosome arrays that have been proposed as a precursor to heterochromatin. We propose a number of ways that the periodic occurrence of An/Tn clusters could reflect evolution and function of genes that express in the germ cell lineage of C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.