ArticleBiophysical journal2006
Determining the ratio of the Gaussian curvature and bending elastic moduli of phospholipids from Q(II) phase unit cell dimensions.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Topological Approach to Measuring the Gaussian Curvature Modulus of Lipid Membranes in Simulation.Physical review letters · 2026Article
- Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Curvature Energetics Determined by Alchemical Simulation on Four Topologically Distinct Lipid Phases.The journal of physical chemistry. B · 2021Article
- Protein-induced membrane curvature alters local membrane tension.Biophysical journal · 2014Article
- Lipid sorting by ceramide and the consequences for membrane proteins.Biophysical journal · 2012Article
- Determining the Gaussian curvature modulus of lipid membranes in simulations.Biophysical journal · 2012Article
- Minimum membrane bending energies of fusion pores.The Journal of membrane biology · 2009Article
- The Gaussian curvature elastic energy of intermediates in membrane fusion.Biophysical journal · 2008Article
- The biophysical function of pulmonary surfactant.Respiratory physiology & neurobiology · 2008Review
- Influence of the lamellar phase unbinding energy on the relative stability of lamellar and inverted cubic phases.Biophysical journal · 2008Article
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Abstract
A method is presented for measuring M, the ratio of the Gaussian (saddle splay) elastic modulus to the bending elastic modulus of a lipid monolayer. The ratio M is determined from measurements of the equilibrium bicontinuous inverted cubic (Q(II)) phase unit cell size in excess water as a function of temperature. The analysis includes the effect of a curvature elastic term that is second-order in the Gaussian curvature, K. Preliminary results using data on DOPE-Me validate the method. The fitted value of M is within 8% of the value estimated in an earlier treatment. The method can be used to measure changes in M due to addition of exogenous lipids and peptides to a host lipid system. The Gaussian elastic modulus has a substantial effect on the stability of fusion intermediates (stalks, hemifusion diaphragms, and fusion pores). Studying the effects of peptides and different lipids on M via this method may yield insights into how fusion protein moieties stabilize intermediates in membrane fusion in vivo. The contribution of the K2 curvature elastic term to the free energy of Q(II) phase and fusion pores explains some features of fusion pore stability and dynamics, and some peculiar observations concerning the mechanism of L(alpha)/Q(II) phase transitions.
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