Evidence map›Paper›PMID 16647857›Full record

ReviewTrends in biochemical sciences2006

Ubiquitin and SUMO systems in the regulation of mitotic checkpoints.

Gustavo J Gutierrez, Ze'ev Ronai

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. An unusual two-step control of CPEB destruction by Pin1.Molecular and cellular biology · 2013
    Article
  6. Role of SUMOylation in full antiestrogenicity.Molecular and cellular biology · 2012
    Article
  7. Protein degradation and the stress response.Seminars in cell & developmental biology · 2012
    Review
  8. Article
  9. Review
  10. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  11. Article
  12. Article
  13. Article
  14. An in vivo study of Cdh1/APC in breast cancer formation.International journal of cancer · 2009
    Article
  15. Article
  16. Article
  17. A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gustavo J GutierrezSignal Transduction Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. gustavo@burnham.org
Ze'ev Ronai
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

JNK AS KEY REGULATOR OF P53 STABILITYR01CA078419 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RONAI, ZE'EV A · 1998 to 2006
$2.4M
NCI NIH HHS CA078419NCI NIH HHS R01 CA078419
6 · The paper itself

Abstract

Proteolysis mediated by the ubiquitin-proteasome system is a crucial regulatory mechanism in signal transduction cascades of temporal cellular processes such as cell division. Two principal subtypes of modular ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) and the Skp1/Cullin-1/F-box protein complex, have emerged as essential regulators of key events in the cell cycle. The importance of these ligases is best illustrated by their roles in the checkpoint and repair pathways or in response to multiple stresses, where they affect activation of the M-phase-promoting factor or proper formation and/or maintenance of the mitotic spindle. Recent studies have considerably improved our understanding of the function of the concerted action of the phosphorylation and ubiquitin or SUMO systems in the regulation of the stability and activity of key components of the mitotic checkpoint.

Indexed as

AnaphaseAnimalsCell DivisionHumansPhosphorylationProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalSignal TransductionSUMO-1 ProteinUbiquitinProteasome Endopeptidase ComplexSUMO-1 ProteinUbiquitin

Identifiers

PMID16647857
PMCPMC3061571
OpenAlexW1993789412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.