ReviewBrain, behavior, and immunity2006
Inflammation and the pathophysiology of work-related musculoskeletal disorders.
Review in Brain, behavior, and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prevalence of and prevention for work-related upper limb disorders among physical therapists: a systematic review.BMC musculoskeletal disorders · 2022Pooled it
- A Mixed Comparisons of Different Intensities and Types of Physical Exercise in Patients With Diseases Related to Oxidative Stress: A Systematic Review and Network Meta-Analysis.Frontiers in physiology · 2021Pooled it
- Work above shoulder level and shoulder complaints: a systematic review.International archives of occupational and environmental health · 2020Pooled it
- Examining the interaction of force and repetition on musculoskeletal disorder risk: a systematic literature review.Human factors · 2013Pooled it
- Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.Journal of biomedicine & biotechnology · 2010Trial
- Intrinsic Predictors of Injury on a Multi-day Wilderness Event for Adolescents and Adult Leaders.American journal of lifestyle medicine · 2026Article
- Occupational ergonomic risk factors and neuropathic pain among South Korean workers: a cross-sectional analysis.Journal of occupational health · 2026Article
- Smartphone addiction and musculoskeletal associated disorders in university students: biomechanical measures and questionnaire survey analysis.European journal of medical research · 2025Article
- Why mindfulness matters in musculoskeletal therapies: a narrative review.Frontiers in psychology · 2025Review
- Reliability of blood inflammatory markers at constant real-life workloads over time: Study protocol.PloS one · 2025Article
- Article
- Wrist Extensor Muscle Fatigue During a Dual Task With Two Muscular and Cognitive Load Levels in Younger and Older Adults.Human factors · 2024Article
- The moderating effect of work-related musculoskeletal disorders in relation to occupational stress and health-related quality of life of construction workers: a cross-sectional research.BMC musculoskeletal disorders · 2024Article
- Physical Activity and High-Sensitivity C-Reactive Protein in Pregnancy: Does It Matter during Leisure or Work?Medicine and science in sports and exercise · 2024Article
- Explainable machine learning framework to predict the risk of work-related neck and shoulder musculoskeletal disorders among healthcare professionals.Frontiers in public health · 2024Article
- Breaking the Fatigue Cycle: Investigating the Effect of Work-Rest Schedules on Muscle Fatigue in Material Handling Jobs.Sensors (Basel, Switzerland) · 2023Article
- Article
- Aging on the Job? The Association Between Occupational Characteristics and Accelerated Biological Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Review
- Causality of occupational exposure on rheumatoid arthritis and ankylosing spondylitis: a two-sample mendelian randomization study.Frontiers in immunology · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Work-related musculoskeletal disorders (MSDs) have accounted for a significant proportion of work injuries and workers' compensation claims in industrialized nations since the late 1980s. Despite epidemiological evidence for the role of repetition and force in the onset and progression of work-related MSDs, complete understanding of these important occupational health problems requires further elucidation of pathophysiological mechanisms of the tissue response, particularly in the early stage of these disorders. Results from several clinical and experimental studies indicate that tissue microtraumas occur as a consequence of performing repetitive and/or forceful tasks, and that this mechanical tissue injury leads to local and perhaps even systemic inflammation, followed by fibrotic and structural tissue changes. Here we review work linking inflammation and the development of work-related MSDs. We also propose a conceptual framework suggesting the potential roles that inflammation may play in these disorders, and how inflammation may contribute to pain, motor dysfunction, and to puzzling psychological symptoms that are often characteristic of patients with work-related MSDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.