ArticleThe Journal of molecular diagnostics : JMD2006
The development of a fluorescence in situ hybridization assay for the detection of dysplasia and adenocarcinoma in Barrett's esophagus.
Article in The Journal of molecular diagnostics : JMD, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Correlation of histology with biomarker status after photodynamic therapy in Barrett esophagus.Cancer · 2008Trial
- The Aberrant Expression of Biomarkers and Risk Prediction for Neoplastic Changes in Barrett's Esophagus-Dysplasia.Cancers · 2024Article
- Utility of ancillary studies in the diagnosis and risk assessment of Barrett's esophagus and dysplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- Recurring Translocations in Barrett's Esophageal Adenocarcinoma.Frontiers in genetics · 2021Article
- Barrett's Esophagus and Esophageal Adenocarcinoma Biomarkers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- An assessment of chromosomal alterations detected by fluorescence in situ hybridisation in pancreatobiliary tract malignancy.BMC gastroenterology · 2020Article
- Point-Counterpoint: Screening and Surveillance for Barrett's Esophagus, Is It Worthwhile?Digestive diseases and sciences · 2018Review
- A Multicenter Study of a Fluorescence In Situ Hybridization Probe Set for Diagnosing High-Grade Dysplasia and Adenocarcinoma in Barrett's Esophagus.Digestive diseases and sciences · 2017Article
- Covalently deposited dyes: a new chromogen paradigm that facilitates analysis of multiple biomarkers in situ.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Fluorescence in situ hybridization identifies high risk Barrett's patients likely to develop esophageal adenocarcinoma.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2016Article
- Diagnostic and Management Implications of Basic Science Advances in Barrett's Esophagus.Current treatment options in gastroenterology · 2015Article
- Prediction of response to endoscopic therapy of Barrett's dysplasia by using genetic biomarkers.Gastrointestinal endoscopy · 2014Article
- Biomarkers of Barrett's esophagus.World journal of gastrointestinal pathophysiology · 2014Review
- Multi-colour FISH in oesophageal adenocarcinoma-predictors of prognosis independent of stage and grade.British journal of cancer · 2014Article
- Guidance on the effective use of upper gastrointestinal histopathology.Frontline gastroenterology · 2014Article
- Role of cytopathology in the diagnosis and management of gastrointestinal tract cancers.Journal of gastrointestinal oncology · 2012Article
- Medical and endoscopic management of high-grade dysplasia in Barrett's esophagus.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2012Article
- Detection of dysplasia in Barrett's esophagus with in vivo depth-resolved nuclear morphology measurements.Gastroenterology · 2011Article
- Predictors of progression in Barrett's esophagus: current knowledge and future directions.The American journal of gastroenterology · 2010Review
- Low Level of Her-2 Locus Amplification by Fluorescent In Situ Hybridization Does Not Correlate with Her-2 Protein Overexpression by Immunohistochemistry in Barrett's Esophagus.Journal of oncology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The goal of this study was to identify a set of fluorescence in situ hybridization probes for the detection of dysplasia and adenocarcinoma in patients with Barrett's esophagus. We examined 170 brushing specimens from 138 patients with Barrett's esophagus or a history of Barrett's esophagus using fluorescence in situ hybridization with probes to 5p15, 5q21-22, centromere 7, 7p12, 8q24.12-13, centromere 9, 9p21, centromere 17, 17p13.1, 17q11.2-12, 20q13.2, and centromere Y. Receiver-operator curves were used to determine the sensitivity and specificity of various four-probe combinations for detecting low-grade dysplasia, high-grade dysplasia, and esophageal adenocarcinoma. Endoscopic biopsy results were used as the gold standard. Numerous four-probe combinations provided a similarly high sensitivity and specificity. Of these, a set consisting of probes to 8q24, 9p21, 17q11.2, and 20q13.2 was found to have a sensitivity and specificity, respectively, of 70% and 89% for low-grade dysplasia, 84% and 93% for high-grade dysplasia, and 94% and 93% for esophageal adenocarcinoma. This probe set was chosen for future prospective clinical evaluations based on its high sensitivity and specificity, its ability to distinguish adenocarcinoma and high-grade or low-grade dysplasia from lesser diagnostic categories, and the favorable signal quality for each of the probes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.