ArticleAmerican journal of respiratory cell and molecular biology2006
Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice.
Article in American journal of respiratory cell and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Towards airway microbiome engineering for improving respiratory health.Advanced drug delivery reviews · 2025Review
- The Role ofInternational journal of molecular sciences · 2025Review
- Korean Guidelines for the Diagnosis and Management of Interstitial Lung Diseases: Sarcoidosis.Tuberculosis and respiratory diseases · 2025Article
- Cellular Recycling Gone Wrong: The Role of Dysregulated Autophagy and Hyperactive mTORC1 in the Pathogenesis of Sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023Article
- Phages and their potential to modulate the microbiome and immunity.Cellular & molecular immunology · 2021Review
- Involvement of Dendritic Cells and Th17 Cells in Induced Tertiary Lymphoid Structures in a Chronic Beryllium Disease Mouse Model.Mediators of inflammation · 2021Article
- Commensal bacteria in the upper respiratory tract regulate susceptibility to infection.Current opinion in immunology · 2020Review
- Models Contribution to the Understanding of Sarcoidosis Pathogenesis: "Are There Good Models of Sarcoidosis?"Journal of clinical medicine · 2020Review
- Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children.Nature communications · 2019Article
- IL-17A Can PromoteFrontiers in immunology · 2019Article
- Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis.Scientific reports · 2017Article
- Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2.American journal of respiratory cell and molecular biology · 2017Article
- Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes.Oncotarget · 2016Article
- The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis.Clinics in chest medicine · 2015Review
- Etiologies of Sarcoidosis.Clinical reviews in allergy & immunology · 2015Review
- Immune response to Propionibacterium acnes in patients with sarcoidosis--in vivo and in vitro.BMC pulmonary medicine · 2015Article
- Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis.Clinical and experimental immunology · 2013Article
- Sarcoidosis--scientific progress and clinical challenges.Nature reviews. Rheumatology · 2011Review
- Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide.American journal of respiratory cell and molecular biology · 2011Article
- Persistent inactivation of macrophage cyclooxygenase-2 in mycobacterial pulmonary inflammation.American journal of respiratory cell and molecular biology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Propionibacterium acnes (PA) is a gram-positive anaerobic bacterium implicated as a putative etiologic agent of sarcoidosis. To characterize the pulmonary immune response to PA, C57BL/6 and BALB/c mice were intraperitoneally sensitized and intratracheally challenged with heat-killed bacteria. C57BL/6 mice challenged with PA developed a cellular immune response characterized by elevations in Th1 cytokines/chemokines, increased numbers of lymphocytes and macrophages in lung lavage fluid, and peribronchovascular granulomatous inflammation composed of T- and B-lymphocytes and epithelioid histiocytes. T-lymphocytes in the lung lavage fluid showed a marked CD4+ cell predominance. In contrast, C57BL/6 mice challenged with Staphylococcus epidermidis (SE), another gram-positive commensal of human skin, and BALB/c mice challenged with PA, showed only a modest induction of Th1 cytokines, less pulmonary inflammation, and no granulomatous changes in the lung. Enhancement of Toll-like receptor expression was seen in PA-exposed C57BL/6 mice within 24 h after exposure, suggesting that induction of innate immunity by PA contributes to the robust, polarized Th1 immune response elicited by this bacterium. These findings suggest that PA-induced pulmonary inflammation may be a useful model for testing the contributions of both bacterial and host factors in the development, maintenance, and resolution of granulomatous inflammation in the lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.