ArticleBMC bioinformatics2006
MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers.
Article in BMC bioinformatics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
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- Methylenetetrahydrofolate reductase polymorphic variants C677T and A1298C in rectal cancer in Slavic population: significance for cancer risk and response to chemoradiotherapy.Frontiers in genetics · 2023Article
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- Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility toFrontiers in genetics · 2022Article
- Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population.Molecular biology reports · 2021Article
- Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.Journal of atherosclerosis and thrombosis · 2020Article
- Estimating linkage disequilibrium from genotypes under Hardy-Weinberg equilibrium.BMC genetics · 2020Article
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- Metagenomic Approaches for Public Health Surveillance of Foodborne Infections: Opportunities and Challenges.Foodborne pathogens and disease · 2019Review
- The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats.Journal of molecular neuroscience : MN · 2018Article
- Haplotype Loci Under Selection in Canadian Durum Wheat Germplasm Over 60 Years of Breeding: Association With Grain Yield, Quality Traits, Protein Loss, and Plant Height.Frontiers in plant science · 2018Article
- Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.PloS one · 2018Article
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- Interferon lambda polymorphisms associate with body iron indices and hepatic expression of interferon-responsive long non-coding RNA in chronic hepatitis C.Clinical and experimental medicine · 2017Article
- Single nucleotide polymorphisms and microsatellites in the canine glutathione S-transferase pi 1 (Canine genetics and epidemiology · 2017Article
- Population genetic structure of Guiana dolphin (Sotalia guianensis) from the southwestern Atlantic coast of Brazil.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these graphics within their website. However, these approaches are limited in their use of data from multiallelic markers and provide limited information in a graphical form.
resultsWe have developed a software package (MIDAS - Multiallelic Interallelic Disequilibrium Analysis Software) for the estimation and graphical display of interallelic linkage disequilibrium. Linkage disequilibrium is analysed for each allelic combination (of one allele from each of two loci), between all pairwise combinations of any type of multiallelic loci in a contig (or any set) of many loci (including single nucleotide polymorphisms, microsatellites, minisatellites and haplotypes). Data are presented graphically in a novel and informative way, and can also be exported in tabular form for other analyses. This approach facilitates visualisation of patterns of linkage disequilibrium across genomic regions, analysis of the relationships between different alleles of multiallelic markers and inferences about patterns of evolution and selection.
conclusionMIDAS is a linkage disequilibrium analysis program with a comprehensive graphical user interface providing novel views of patterns of linkage disequilibrium between all types of multiallelic and biallelic markers.
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