ArticleDigestive diseases and sciences2006
Growth arrest and decrease of alpha-SMA and type I collagen expression by palmitic acid in the rat hepatic stellate cell line PAV-1.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- The Effects of Freshwater Clam (Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Research on promoting liver fibrosis injury by the targeted regulation of miR-202 for HGF to activate HSC.Irish journal of medical science · 2020Article
- Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells.Annals of translational medicine · 2020Article
- The expression of ETAR in liver cirrhosis and liver cancer.Cancer biology & therapy · 2017Article
- Experimental models of liver fibrosis.Archives of toxicology · 2016Review
- Immune and inflammatory pathways in NASH.Hepatology international · 2013Review
- Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice.Hepatology (Baltimore, Md.) · 2013Article
- Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes.Journal of physiology and biochemistry · 2011Review
- Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis.BMC gastroenterology · 2010Article
- Enhanced effect of soluble transforming growth factor-beta receptor II and IFN-gamma fusion protein in reversing hepatic fibrosis.European journal of medical research · 2010Article
- CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.Journal of gastroenterology and hepatology · 2010Article
- Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence.Cancer science · 2009Article
- Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells.Molecular biology of the cell · 2008Article
- Down-regulation of transforming growth factor beta 1/activin receptor-like kinase 1 pathway gene expression by herbal compound 861 is related to deactivation of LX-2 cells.World journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver fibrosis is characterized by an activation of hepatic stellate cells (HSC). During primary culture HSC evolve from a quiescent into an activated phenotype which is characterized by alpha-smooth muscle actin (alpha-SMA) up-regulation, increase in cell growth, and extracellular matrix secretion. HSC culture with trans-resveratrol can lead to deactivation of myofibroblast-like HSC. We used an HSC line, PAV-1, to check the role of retinol and palmitic acid in the deactivation process of HSC. Using mass and metabolic-based methods, Western blot and immunocytochemistry assays, we demonstrated that treatment with palmitic acid (75 muM) alone or in combination with retinol (2 muM) significantly decreased cell proliferation and alpha-SMA expression. We also established that the association of both compounds strongly decreased collagen type I expression. Our results suggest the potential use of palmitic acid alone or in combination with retinol to induce HSC deactivation.
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