ArticleCell regulation1991
Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family.
Article in Cell regulation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- The Roles of EphB2 in Cancer.Frontiers in cell and developmental biology · 2022Review
- Comprehensive analysis of NMR data using advanced line shape fitting.Journal of biomolecular NMR · 2017Article
- Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.The Journal of biological chemistry · 2008Article
- Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Roles of Eph receptors and ephrins in segmental patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- Article
- An Eph receptor regulates integrin activity through R-Ras.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.The EMBO journal · 1996Article
- Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9.The Journal of cell biology · 1996Article
- Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Embryonic stem cells express multiple Eph-subfamily receptor tyrosine kinases.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.The EMBO journal · 1995Article
- Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.The EMBO journal · 1994Article
- eph, the largest known family of putative growth factor receptors.British journal of cancer · 1994Review
- Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.Molecular and cellular biology · 1993Article
- Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chicken embryo kinase 5 (Cek5) is a transmembrane tyrosine kinase of the Eph family that was identified by screening a 10-d chicken embryo cDNA expression library with anti-phosphotyrosine antibodies. The extracellular region of Cek5 contains a cysteine rich N-terminal subdomain and a C-terminal subdomain mostly devoid of cysteines and comprising two repeats similar to fibronectin type III repeats. Immunoblotting experiments with anti-Cek5 polyclonal antibodies indicated that Cek5 is a membrane-associated 120-kDa protein containing intramolecular (but not intermolecular) disulfide bonds. Cek5 is already expressed in 2-d-old chicken embryos and is also expressed, at higher levels, later in development. In 10-d-old chicken embryos, Cek5 is expressed at substantial levels in nearly all the tissues examined, whereas in adult it is expressed predominantly in the brain. The expression of Cek5 in the brain gradually diminishes during embryonic development, whereas in the skeletal muscle of the thigh a sharp decrease in Cek5 expression was detected at the time of terminal muscle differentiation. Its wide tissue distribution throughout development and its sustained expression in adult brain suggest that Cek5 is an important component of signal transduction pathways, likely to interact with a widely distributed and important ligand, which is as yet unknown.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.