ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2007
Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed.
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- Quetiapine improves response inhibition in alcohol dependent patients: a placebo-controlled pilot study.Pharmacology, biochemistry, and behavior · 2012Trial
- A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving.Psychopharmacology · 2011Trial
- The effect of dopamine agonists on cognitive functions in non-demented early-mild Parkinson's disease patients.Functional neurologyTrial
- Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment.Neurobiology of stress · 2024Review
- Assessing attention and impulsivity in the variable stimulus duration and variable intertrial interval rodent continuous performance test schedules using dopamine receptor antagonists in female C57BL/6JRj mice.Psychopharmacology · 2023Article
- Inhibition of ventral tegmental area projections to the nucleus accumbens shell increases premature responding in the five-choice serial reaction time task in rats.Brain structure & function · 2023Article
- Effect of atomoxetine on ADHD-pain hypersensitization comorbidity in 6-OHDA lesioned mice.Pharmacological reports : PR · 2023Article
- Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023Article
- Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Nucleus accumbens shell modulates seizure propagation in a mouse temporal lobe epilepsy model.Frontiers in cell and developmental biology · 2022Article
- Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice.Frontiers in neuroscience · 2022Article
- Reduced exploratory behavior in neuronal nucleoredoxin knockout mice.Redox biology · 2021Article
- HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits.Cells · 2021Review
- Temporally Specific Roles of Ventral Tegmental Area Projections to the Nucleus Accumbens and Prefrontal Cortex in Attention and Impulse Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Rejecting impulsivity as a psychological construct: A theoretical, empirical, and sociocultural argument.Psychological review · 2021Article
- Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.Cellular and molecular life sciences : CMLS · 2021Article
- Pair housing, but not using a controlled reinforcer frequency procedure, attenuates the modulatory effect of probability presentation order on amphetamine-induced changes in risky choice.Behavioural brain research · 2020Article
- Pro-cognitive effect of 1MeTIQ on recognition memory in the ketamine model of schizophrenia in rats: the behavioural and neurochemical effects.Psychopharmacology · 2020Article
- Review
28 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Nucleus accumbens (NAC) dopamine may play a role in attentional and executive processes, as it modulates cortico-limbic inputs, including afferents from the prefrontal cortex. The present study examined the role of NAC dopamine D1 and D2 receptors in visual attentional processes and response control in rats as assessed in the five-choice serial reaction time task (5CSRT). Rats were trained to detect the location of brief (0.5 s) visual targets presented randomly in an array of five apertures to receive food reward. They were tested after bilateral infusions of a D1 receptor antagonist (SCH 23390) and agonist (SKF 38393) and a D2 receptor antagonist (sulpiride) and agonist (quinpirole) into the NAC. While intra-NAC SCH 23390 decreased accurate responding and increased response omissions, SKF 38393 improved accuracy and decreased omissions at the lowest dose (0.1 microg/side). At higher doses, SKF 38393 increased premature 'impulsive' responding. Sulpiride impaired the attentional accuracy of responding and slowed the latency to collect the earned food reward. By contrast, intra-NAC infusions of quinpirole did not significantly affect attentional accuracy, but increased perseverative responding. Optimal performance on the 5CSRT depends on both D1 and D2 receptors in the NAC, but they modulate different aspects of performance. D1 receptor agents had more selective effects on attentional accuracy while D2 receptor stimulation did not affect accuracy or premature responses, but enhanced perseverative responding. The data are discussed in terms of the different functions of NAC dopamine receptors in the processing of information from its different cortico-limbic inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.