ArticleAntimicrobial agents and chemotherapy2006
Comparative in vitro efficacies of various catheter lock solutions.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01592032 (Concentration and Antibiotic Activity in Antibiotic Lock Solutions), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Concentration and Antibiotic Activity in Antibiotic Lock Solutions
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anticoagulants and antiplatelet agents for preventing central venous haemodialysis catheter malfunction in patients with end-stage kidney disease.The Cochrane database of systematic reviews · 2016Pooled it
- Successful Salvage of Central Venous Catheters in Patients with Catheter-Related or Central Line-Associated Bloodstream Infections by Using a Catheter Lock Solution Consisting of Minocycline, EDTA, and 25% Ethanol.Antimicrobial agents and chemotherapy · 2016Trial
- Microbial interactions of EDTA: recent advances and biological applications in the context of natural product modulation.Frontiers in antibiotics · 2026Review
- The Hidden Fortress: A Comprehensive Review of Fungal Biofilms with Emphasis onJournal of fungi (Basel, Switzerland) · 2025Review
- Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producingiScience · 2023Article
- Actions of N-acetylcysteine, daptomycin, vancomycin, and linezolid on methicillin-resistant Staphylococcus aureus biofilms in the ventriculoperitoneal shunt infections: an experimental study.Chinese neurosurgical journal · 2022Article
- Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.Current medical mycology · 2022Article
- Antibacterial Activity of Some Molecules Added to Rabbit Semen Extender as Alternative to Antibiotics.Animals : an open access journal from MDPI · 2021Article
- Destruction of Staphylococcus aureus biofilms by combining an antibiotic with subtilisin A or calcium gluconate.Scientific reports · 2021Article
- Ethanol Lock Therapy Markedly Reduces Catheter-Related Blood Stream Infections in Adults Requiring Home Parenteral Nutrition: A Retrospective Study From a Tertiary Medical Center.JPEN. Journal of parenteral and enteral nutrition · 2020Article
- Activity of taurolidine gels on ex vivo periodontal biofilm.Clinical oral investigations · 2018Article
- Comparative Efficacies of Antimicrobial Catheter Lock Solutions for Fungal Biofilm Eradication in an in Vitro Model of Catheter-Related Fungemia.Journal of fungi (Basel, Switzerland) · 2017Article
- In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2016Article
- In vitro activity of taurolidine gel on bacteria associated with periodontitis.Clinical oral investigations · 2016Article
- In vitro efficacy of daptomycin and teicoplanin combined with ethanol, clarithromycin or gentamicin as catheter lock solutions.BMC microbiology · 2015Article
- EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care.Advances in wound care · 2015Review
- Fungal Biofilms: In Vivo Models for Discovery of Anti-Biofilm Drugs.Microbiology spectrum · 2015Article
- From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms.Microbiology spectrum · 2015Article
- Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy.The Journal of antimicrobial chemotherapy · 2014Article
- Bench-to-bedside review: Challenges of diagnosis, care and prevention of central catheter-related bloodstream infections in children.Critical care (London, England) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.