ArticleAntimicrobial agents and chemotherapy2006
Complex genetic structures with repeated elements, a sul-type class 1 integron, and the blaVEB extended-spectrum beta-lactamase gene.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Antimicrobial resistance in meat and meat products from Asia: An urgent one health challenge- a systematic review and meta-analysis.Poultry science · 2025Pooled it
- Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance inInternational journal of molecular sciences · 2023Pooled it
- How Do Transposable Elements Activate Expression of Transcriptionally Silent Antibiotic Resistance Genes?International journal of molecular sciences · 2022Review
- Genomic characterization of multidrug-resistantMicrobial genomics · 2022Article
- Article
- Genetic Characterization of a blaVEB-2-Carrying Plasmid in Vibrio parahaemolyticus.Antimicrobial agents and chemotherapy · 2016Article
- Integron-borne transmission of VEB-1 extended-spectrum β-lactamase in Pseudomonas aeruginosa in a tertiary care hospital in India.Antimicrobial agents and chemotherapy · 2014Article
- Molecular characterization of blaNDM-1 in a sequence type 235 Pseudomonas aeruginosa isolate from France.Antimicrobial agents and chemotherapy · 2013Article
- Homology modeling and virtual screening approaches to identify potent inhibitors of VEB-1 β-lactamase.Theoretical biology & medical modelling · 2013Article
- Identification of New Delhi metallo-β-lactamase 1 in Acinetobacter lwoffii of food animal origin.PloS one · 2012Article
- Diversity of clavulanic acid-inhibited extended-spectrum β-lactamases in Aeromonas spp. from the Seine River, Paris, France.Antimicrobial agents and chemotherapy · 2011Article
- Pseudomonas aeruginosa: resistance to the max.Frontiers in microbiology · 2011Article
- Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2010Article
- ISCR2, another vehicle for bla(VEB) gene acquisition.Antimicrobial agents and chemotherapy · 2009Article
- A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure.Antimicrobial agents and chemotherapy · 2009Article
- Genetic structure associated with blaOXA-18, encoding a clavulanic acid-inhibited extended-spectrum oxacillinase.Antimicrobial agents and chemotherapy · 2008Article
- Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene.Antimicrobial agents and chemotherapy · 2008Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Two clinical isolates of Pseudomonas aeruginosa, TL-1 and TL-2, were isolated from a patient transferred from Bangladesh and hospitalized for osteomyelitis in Paris, France. P. aeruginosa TL-1 expressed the extended-spectrum beta-lactamase VEB-1a and was susceptible only to imipenem and colistin, while P. aeruginosa TL-2 expressed only the naturally occurring bla(AmpC) gene at a basal level and exhibited a wild-type beta-lactam resistance phenotype. In TL-1, the typical 5'-end conserved sequence (5'-CS) region of class 1 integrons usually present upstream of the bla(VEB-1a) gene was replaced by a truncated 3'-CS and a 135-bp repeated element (Re). Downstream of the bla(VEB-1a) gene, an insertion sequence, ISPa31 disrupted by ISPa30, and an orf513 sequence, belonging to a common region (conserved region 1 [CR1]) immediately upstream of the aphA-6 gene, were present. Further downstream, a second truncated 3'-CS region in direct repeat belonged to In51, an integron containing two gene cassettes (aadA6 and the OrfD cassette). Thus, the overall structure corresponded to a sul-type class 1 integron termed In121. Genetic analyses revealed that both isolates were clonally related and differed by a ca. 100-kb fragment that contained In121. Both isolates contained another integron, In122, that carried three gene cassettes: aadB, dfrA1, and the OrfX cassette. This work identifies for the first time the spread of Re-associated bla(VEB) genes located on a sul-type integron. It also reports for the first time a CR1 element in P. aeruginosa that is associated with an aminoglycoside resistance aphA-6 gene that is expressed from a composite promoter.
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