ArticleAntimicrobial agents and chemotherapy2006
Antifungal activity of C-27 steroidal saponins.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
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- Sterol divergence across eukaryotic kingdoms determines membrane susceptibility to saponins, a class of plant defense compounds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A comprehensive review on plant-derived bioactive saponins as promising antimicrobial agents: from bioavailability challenges, molecular mechanistic insights to therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Elucidation of the biosynthetic pathways of timosaponins reveals the antifungal mechanisms in Anemarrhena asphodeloides.Journal of advanced research · 2025Article
- Comparative metabolites profiling of different solvent extracts of Asparagus species cladodes using liquid chromatography-mass spectrometry-based metabolomics and molecular networking.Phytochemical analysis : PCA · 2025Article
- Asteroid Saponins: A Review of Their Bioactivity and Selective Cytotoxicity.Marine drugs · 2024Review
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- Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles.Molecules (Basel, Switzerland) · 2023Review
- Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways.Metabolites · 2023Review
- Potential Use ofPlants (Basel, Switzerland) · 2022Review
- Dereplication of Bioactive Spirostane Saponins fromJournal of natural products · 2021Article
- Hunting Bioactive Molecules from theMolecules (Basel, Switzerland) · 2021Review
- Microwave technology: a novel approach to the transformation of natural metabolites.Chinese medicine · 2021Review
- Structure, Bioactivity and Analytical Methods for the Determination ofMolecules (Basel, Switzerland) · 2021Review
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- Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally inMolecules (Basel, Switzerland) · 2020Article
- Fermentative capabilities of native yeast strains grown on juices from different Agave species used for tequila and mezcal production.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Antifungal Activity ofPlants (Basel, Switzerland) · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds 1 to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.