ArticleJournal of virology2006
Comparison of simian immunodeficiency virus SIVagmVer replication and CD4+ T-cell dynamics in vervet and sabaeus African green monkeys.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 80 citations in OpenAlex.
- Hematological consequences of environmental change during dewilding of rhesus macaques.Nature communications · 2026Article
- It's all in the gut: the central role of the gut and microbiome in preventing disease progression in simian immunodeficiency viruses infected African nonhuman primates.Current opinion in HIV and AIDS · 2025Review
- Review
- Milk Transmission of Mammalian Retroviruses.Microorganisms · 2023Review
- Translational Models to Predict Target Concentrations for Pre-Exposure Prophylaxis in Women.AIDS research and human retroviruses · 2022Review
- Epigenetic Reprogramming Leads to Downregulation of CD4 and Functional Changes in African Green Monkey Memory CD4Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Review
- An Evolutionary Model of Progression to AIDS.Microorganisms · 2020Article
- Multivariate profiling of African green monkey and rhesus macaque T lymphocytes.Scientific reports · 2019Article
- Does B Cell Follicle Exclusion of CD8+ T Cells Make Lymph Nodes Sanctuaries of HIV Replication?Frontiers in immunology · 2019Review
- Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?Frontiers in immunology · 2017Review
- The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques.PLoS pathogens · 2015Article
- Local Virus Extinctions following a Host Population Bottleneck.Journal of virology · 2015Article
- Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells.Journal of virology · 2014Article
- Live attenuated tetravalent dengue virus host range vaccine is immunogenic in African green monkeys following a single vaccination.Journal of virology · 2014Article
- Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Host gene evolution traces the evolutionary history of ancient primate lentiviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure.Immunological reviews · 2013Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
The simian immunodeficiency viruses (SIV) naturally infect a wide range of African primates, including African green monkeys (AGM). Despite moderate to high levels of plasma viremia in naturally infected AGM, infection is not associated with immunodeficiency. We recently reported that SIVagmVer90 isolated from a naturally infected vervet AGM induced AIDS following experimental inoculation of pigtailed macaques. The goal of the present study was to evaluate the replication of this isolate in two species of AGM, sabaeus monkeys (Chlorocebus sabaeus) and vervets (C. pygerythrus). Inoculation of sabaeus AGM with SIVagmVer90 resulted in low and variable primary and set-point viremia (<10(2) to 10(4) copies/ml). In contrast, inoculation of vervet AGM with either SIVagmVer90 or blood from a naturally infected vervet (Ver1) resulted in high primary viremia and moderate plateau levels, similar to the range seen in naturally infected vervets from this cohort. CD4(+) T cells remained stable throughout infection, even in AGM with persistent high viremia. Despite the lack of measurable lymphadenopathy, infection was associated with an increased number of Ki-67(+) T cells in lymph node biopsies, consistent with an early antiviral immune response. The preferential replication of SIVagmVer in vervet versus sabaeus AGM shows that it is critical to match AGM species and SIV strains for experimental models of natural SIV infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.