ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis and poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets.Journal of neurovirology · 2021Article
- HIV-associated synaptic degeneration.Molecular brain · 2017Review
- Translating the brain transcriptome in neuroAIDS: from non-human primates to humans.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment.PloS one · 2012Article
- Illuminating viral infections in the nervous system.Nature reviews. Immunology · 2011Review
- Article
- Inflammation in neuroviral diseases.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders.Genome medicine · 2010Article
- Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.Journal of virology · 2010Article
- A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection.Neuron · 2009Review
- Early antiretroviral treatment prevents the development of central nervous system abnormalities in simian immunodeficiency virus-infected rhesus monkeys.AIDS (London, England) · 2009Article
- Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positive subjects.Journal of virology · 2008Article
- Glial connexins and gap junctions in CNS inflammation and disease.Journal of neurochemistry · 2008Review
- Behavioral and neurophysiological hallmarks of simian immunodeficiency virus infection in macaque monkeys.Journal of neurovirology · 2008Review
- Virus-host interaction in the simian immunodeficiency virus-infected brain.Journal of neurovirology · 2008Review
- Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques.The Journal of clinical investigation · 2008Article
- Adding fuel to the fire: methamphetamine enhances HIV infection.The American journal of pathology · 2008Article
- Neuroinvasion of fluorescein-positive monocytes in acute simian immunodeficiency virus infection.Journal of virology · 2007Article
- Identification and characterization of a Y-like primate retinal ganglion cell type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
CNS abnormalities can be detected during chronic human immunodeficiency virus (HIV) infection, before the development of opportunistic infections or other sequelae of immunodeficiency. However, although end-stage dementia caused by HIV has been linked to the presence of infected and activated macrophages and microglia in the brain, the nature of the changes resulting in the motor and cognitive disorders in the chronic stage is unknown. Using simian immunodeficiency virus-infected rhesus monkeys, we sought the molecular basis for CNS dysfunction. In the chronic stable stage, nearly 2 years after infection, all animals had verified CNS functional abnormalities. Both virus and infiltrating lymphocytes (CD8+ T-cells) were found in the brain. Molecular analysis revealed that the expression of several immune response genes was increased, including CCL5, which has pleiotropic effects on neurons as well as immune cells. CCL5 was significantly upregulated throughout the course of infection, and in the chronic phase was present in the infiltrating lymphocytes. We have identified an altered state of the CNS at an important stage of the viral-host interaction, likely arising to protect against the virus but in the long term leading to damaging processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.