ReviewCurrent atherosclerosis reports2006
Vascular shear stress and activation of inflammatory genes.
Review in Current atherosclerosis reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Uncovering pre-cytokinetic block in cancer cells under shear stress using a disturbed flow-generating device.Scientific reports · 2025Article
- Mimicking of Blood Flow Results in a Distinct Functional Phenotype in Human Non-Adherent Classical Monocytes.Biology · 2021Article
- Increases in microvascular perfusion and tissue oxygenation via pulsed electromagnetic fields in the healthy rat brain.Journal of neurosurgery · 2015Article
- Single-cell imaging of mechanotransduction in endothelial cells.Progress in molecular biology and translational science · 2014Review
- Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state.Free radical biology & medicine · 2013Review
- Voice rest versus exercise: a review of the literature.Journal of voice : official journal of the Voice Foundation · 2010Review
- Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function.Molecular & cellular biomechanics : MCB · 2010Article
- Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The role of cellular adaptation to mechanical forces in atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2008Review
- Monocyte-endothelial cell interactions in the development of atherosclerosis.Trends in cardiovascular medicine · 2008Review
- Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stress.Thrombosis research · 2008Article
- Isolation of endothelial cells and vascular smooth muscle cells from internal mammary artery tissue.Ochsner journal · 2007Article
- The influence of heart failure self-care on health outcomes: hypothetical cardioprotective mechanisms.The Journal of cardiovascular nursingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerotic lesions form preferentially at distinct sites in the arterial tree, especially at or near branch points, bifurcations, and curvatures where there is disturbed or oscillatory blood flow. In contrast, straight regions of the vasculature exhibit uniform laminar shear stress, which is atheroprotective. The ability of laminar flow to exert an anti-inflammatory effect on the endothelial cell lining of the blood vessel is revealed by preventing monocyte adhesion, proliferation, and apoptosis. Changes in endothelial cell gene expression in response to laminar shear stress reflect these changes in cell physiology with the demonstration that physiologic flow inhibits the expression of inflammatory genes. Thus, shear stress is critically important in regulating vascular physiology and pathobiology of the vessel wall via the modulation of endothelial cell gene expression.
Indexed as
Identifiers
16640961What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.