ArticleJournal of human genetics2006
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.
Article in Journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.bioRxiv : the preprint server for biology · 2026Article
- Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire.Frontiers in immunology · 2023Article
- Humanin and diabetes mellitus: A review ofWorld journal of diabetes · 2022Review
- The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration.Frontiers in cell and developmental biology · 2022Review
- Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.The protein journal · 2021Article
- Mitochondrial-derived peptides in energy metabolism.American journal of physiology. Endocrinology and metabolism · 2020Review
- Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.Molecular medicine reports · 2020Article
- Sex differences in the late first trimester human placenta transcriptome.Biology of sex differences · 2018Article
- Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.PloS one · 2018Article
- Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.Seminars in cancer biology · 2017Review
- Functional Mitochondria in Health and Disease.Frontiers in endocrinology · 2017Review
- Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.Oxidative medicine and cellular longevity · 2017Review
- Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.Physiological reports · 2016Article
- The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.Investigative ophthalmology & visual science · 2016Article
- Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.Molecular neurobiology · 2015Review
- Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.TheScientificWorldJournal · 2014Article
- Humanin: a harbinger of mitochondrial-derived peptides?Trends in endocrinology and metabolism: TEM · 2013Article
- Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.Cell death & disease · 2013Article
- Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.PloS one · 2012Article
- The Role of Mitochondria in AMD: Current Knowledge and Future Applications.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease. Because HN was recently found to block proapoptotic Bax function and exert its versatile cytoprotective effects in association with an increase in ATP levels, HN expression may thus reflect a physiological response against degenerative changes in the muscles of patients with CPEO. We found HN expression in all four patients examined, each of whom had different mitochondrial DNA mutations including two different single DNA deletions, multiple deletions, and no major mutations detected. We also found that HN expression was not linked to focal cytochrome c deficiency, strongly associated with the subtype of CPEO with single deletions. These results suggest that HN expression is more closely related to degenerative changes in all types of CPEO. Notably, HN was also expressed in non-degenerative muscle fibers of patients with CPEO or Leigh syndrome, who had the 8993T>G mutation in the mitochondrial ATPase 6 gene known to be associated with impaired ATP synthesis. Collectively, our findings suggest that HN may be specifically expressed in response to defects in energy production in muscles with mitochondrial abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.