ReviewExperimental brain research2006
Parkinson's disease: a rethink of rodent models.
Review in Experimental brain research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease.Glycoconjugate journal · 2022Review
- Progress toward Alzheimer's disease treatment: Leveraging the Achilles' heel of Aβ oligomers?Protein science : a publication of the Protein Society · 2020Review
- [Cellular replacement strategies and adult neurogenesis in idiopathic Parkinson's disease].Der Nervenarzt · 2016Review
- Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease.Molecular neurodegeneration · 2016Article
- Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?International journal of molecular sciences · 2015Review
- Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.Nature communications · 2015Article
- Mitochondrial oxidative stress in aging and healthspan.Longevity & healthspan · 2014Review
- Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans.PloS one · 2014Article
- Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity.Neural plasticity · 2014Review
- Advances in non-dopaminergic treatments for Parkinson's disease.Frontiers in neuroscience · 2014Review
- Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases?BioMed research international · 2014Review
- Adult neurogenesis in Parkinson's disease.Cellular and molecular life sciences : CMLS · 2013Review
- The pathways of mitophagy for quality control and clearance of mitochondria.Cell death and differentiation · 2013Review
- Oxidative stress in genetic mouse models of Parkinson's disease.Oxidative medicine and cellular longevity · 2012Review
- Tracking extranigral degeneration in animal models of Parkinson's disease: quest for effective therapeutic strategies.Journal of neurochemistry · 2011Review
- Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease.Antioxidants & redox signaling · 2011Article
- N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse.Annals of neurology · 2011Article
- Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.Nature reviews. Drug discovery · 2011Review
- The genetics of Parkinson disease.Journal of geriatric psychiatry and neurology · 2010Review
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.Human molecular genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from genetic risk factors, environmental exposures and most likely a combination of both. Rodent models of parkinsonism aim to reproduce key pathogenic features of the syndrome including movement disorder induced by the progressive loss of dopaminergic neurons in the substantia nigra, accompanied by the formation of alpha-synuclein containing Lewy body inclusions. Despite the creation of many excellent models, both chemically induced and genetically engineered, there is none that accurately demonstrates these features. Recent pathological staging studies in man have also emphasized the significant non-CNS component of PD that has yet to be tackled. Herein, we summarize rodent models of PD and what they offer to the field, and suggest future challenges and opportunities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.