ArticleBMC evolutionary biology2006
A high density of ancient spliceosomal introns in oxymonad excavates.
Article in BMC evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Genome-wide identification and comprehensive analysis of the FtsH gene family in wheat.Molecular biology reports · 2025Article
- The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion.Molecular biology and evolution · 2019Article
- Characterization of newly gained introns in Daphnia populations.Genome biology and evolution · 2014Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Article
- Broadly sampled multigene analyses yield a well-resolved eukaryotic tree of life.Systematic biology · 2010Article
- An overview of the introns-first theory.Journal of molecular evolution · 2009Article
- Evolution of GHF5 endoglucanase gene structure in plant-parasitic nematodes: no evidence for an early domain shuffling event.BMC evolutionary biology · 2008Article
- Evolutionary convergence on highly-conserved 3' intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome.PLoS genetics · 2008Article
- Spliceosomal introns as tools for genomic and evolutionary analysis.Nucleic acids research · 2008Review
- Intron mis-splicing: no alternative?Genome biology · 2008Review
- Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing.BMC evolutionary biology · 2007Article
- Protecting exons from deleterious R-loops: a potential advantage of having introns.Biology direct · 2007Article
- Conserved intron positions in ancient protein modules.Biology direct · 2007Article
- The Naegleria genome: a free-living microbial eukaryote lends unique insights into core eukaryotic cell biology.Research in microbiologyReview
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCertain eukaryotic genomes, such as those of the amitochondriate parasites Giardia and Trichomonas, have very low intron densities, so low that canonical spliceosomal introns have only recently been discovered through genome sequencing. These organisms were formerly thought to be ancient eukaryotes that diverged before introns originated, or at least became common. Now however, they are thought to be members of a supergroup known as excavates, whose members generally appear to have low densities of canonical introns. Here we have used environmental expressed sequence tag (EST) sequencing to identify 17 genes from the uncultivable oxymonad Streblomastix strix, to survey intron densities in this most poorly studied excavate group.
resultsWe find that Streblomastix genes contain an unexpectedly high intron density of about 1.1 introns per gene. Moreover, over 50% of these are at positions shared between a broad spectrum of eukaryotes, suggesting they are very ancient introns, potentially present in the last common ancestor of eukaryotes.
conclusionThe Streblomastix data show that the genome of the ancestor of excavates likely contained many introns and the subsequent evolution of introns has proceeded very differently in different excavate lineages: in Streblomastix there has been much stasis while in Trichomonas and Giardia most introns have been lost.
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