ArticleGenetica2006
Ovis aries POU1F1 gene: cloning, characterization and polymorphism analysis.
Article in Genetica, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Association of DGAT1 and POU1F1 Gene Polymorphisms With the Milk Traits in the Cross-Bred Hamdani Sheep Bred Under Extensive Management.Veterinary medicine and science · 2025Article
- Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats.Archives animal breeding · 2023Article
- Article
- Associations of POU1F1 gene polymorphisms and protein structure changes with growth traits and blood metabolites in two Iranian sheep breeds.Journal of genetics · 2014Article
- Association of pituitary specific transcription factor-1 (POU1F1) gene polymorphism with growth and biometric traits and blood metabolites in Iranian Zel and Lori-Bakhtiari sheep.Molecular biology reports · 2014Article
- Polymorphism of sheep POU1F1 gene exon 6 and 3'UTR region and their association with milk production traits.Iranian journal of veterinary research · 2014Article
- Identification of novel SNPs in the Sarda breed goats POU1F1 gene and their association with milk productive performance.Molecular biology reports · 2013Article
- PCR-SSCP Variation of IGF1 and PIT1 Genes and Their Association with Estimated Breeding Values of Growth Traits in Makooei Sheep.Genetics research international · 2013Article
- Analysis of polymorphism within POU1F1 gene in relation to milk production traits in dairy Sarda sheep breed.Molecular biology reports · 2012Article
- Polymorphisms of caprine POU1F1 gene and their association with litter size in Jining Grey goats.Molecular biology reports · 2012Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
POU1F1 (PIT-1/GHF-1) is a transcription factor with critical role in the transcriptional regulation of multiple genes in the pituitary and also important for the survival, differentiation and proliferation of three pituitary cell types. To understand the regulation of POU1F1 gene in Ovis aries we report its cloning, sequencing and characterization. The sequenced 5787 bp included six exons and two complete introns. Ovine POU1F1 gene has a high level of conservation with its bovine, human and rat counterparts showing 98.2%, 91.2% and 86.2% of similarity at the coding level, respectively. All six exons were analyzed for polymorphism detection in 100 animals of the Portuguese indigenous ovine breed 'Churra da Terra Quente'. One polymorphism was found at codon 58 in exon 2, in one allele of 4 animals leading to a change from cysteine to tyrosine (2% allelic frequency). In exon 3 two polymorphisms were detected: a G to A transition altering a glycine to an asparagine at codon 89 in one allele of one animal (0.5% allelic frequency) and another G to A transition at codon 105 converting an alanine into a threonine in one allele of 3 animals (1.5% allelic frequency). These polymorphisms might change the structure of the POU1F1 protein and modify gene-expression. In intron 4, an A to G transition was detected in one allele of six animals (3% allelic frequency). Exons 1, 4 and 6 showed no polymorphisms.
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