ReviewParasitology research2006
Schistosomiasis--a century searching for chemotherapeutic drugs.
Review in Parasitology research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Neglected tropical diseases: survey and geometry of randomised evidence.BMJ (Clinical research ed.) · 2012Pooled it
- Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?RSC medicinal chemistry · 2020Review
- UHPLC-MS-Based Metabolomics Analysis Reveals the Process of Schistosomiasis in Mice.Frontiers in microbiology · 2020Article
- In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms.PloS one · 2019Article
- PZQ Therapy: How Close are we in the Development of Effective Alternative Anti-schistosomal Drugs?Infectious disorders drug targets · 2019Review
- Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data.Scientific reports · 2018Article
- Suppression ofInternational journal of molecular sciences · 2018Article
- Acetylcholinesterase and Nicotinic Acetylcholine Receptors in Schistosomes and Other Parasitic Helminths.Molecules (Basel, Switzerland) · 2017Review
- Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.PLoS neglected tropical diseases · 2017Article
- Universal Stress Proteins as New Targets for Environmental and Therapeutic Interventions of Schistosomiasis.International journal of environmental research and public health · 2016Review
- Functional characterisation of Schistosoma japonicum acetylcholinesterase.Parasites & vectors · 2016Article
- Human TNF-α induces differential protein phosphorylation in Schistosoma mansoni adult male worms.Parasitology research · 2016Article
- Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms.PLoS neglected tropical diseases · 2015Article
- Stem cell therapy for the treatment of parasitic infections: is it far away?Parasitology research · 2014Article
- Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms.BioMed research international · 2014Article
- Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?Parasitology research · 2014Article
- Dihydroartemisinin: a new story of an old drug against Schistosoma mansoni infection.Parasitology research · 2014Article
- Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis.International journal for parasitology. Drugs and drug resistance · 2013Article
- Current drug targets for helminthic diseases.Parasitology research · 2013Review
- Molecular and functional characterization of a putative PA28γ proteasome activator orthologue in Schistosoma mansoni.Molecular and biochemical parasitology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis affects 200 million individuals in underdeveloped and developing regions and is a growing concern for travelers worldwide. There has been evidence of resistance to the praziquantel-based therapy and reports of acute-disease manifestation; therefore, other drugs affecting different stages of the schistosome parasites life cycle and alternative therapeutic regimens should be developed and become accessible. The present review results from a comprehensive search in the scientific literature for substances and compounds tested in the past centennial for schistosomiasis therapy. We gathered over 40 drugs providing information on therapeutic action in humans or animal model, toxicity, susceptible Schistosoma stages, species, etc. The drugs were grouped according to their known metabolic effects on the parasite, whether they are on membrane structure and function, carbohydrate metabolism, protein synthesis and function, or on nucleic acid metabolism. We discuss the current knowledge of drug-target interactions, their mechanism of action and possible therapy combinations. Furthermore, based in the literature and in our own experience with large-scale Schistosoma mansoni genome and transcriptome analyses, we put forward several recently described gene products that are promising target candidates for existing or new drugs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.