ArticleOncogene2006
Knockdown of Sox4 expression by RNAi induces apoptosis in ACC3 cells.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- SOX4 is a potential prognostic factor in human cancers: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Pooled it
- Single-Nucleus Transcriptomes of Lacrimal Gland Adenoid Cystic Carcinoma With Different Growth Patterns.Head & neck · 2026Article
- Reconstruction and analysis of the aberrant lncRNA-miRNA-mRNA network based on competitive endogenous RNA in adenoid cystic carcinoma of the salivary gland.Translational cancer research · 2021Article
- 2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors.International journal of molecular sciences · 2021Review
- Article
- SOX4 regulates invasion of bladder cancer cells via repression of WNT5a.International journal of oncology · 2019Article
- FHL3 links cell growth and self-renewal by modulating SOX4 in glioma.Cell death and differentiation · 2019Article
- UCA1 promotes cell proliferation and invasion and inhibits apoptosis through regulation of the miR129-SOX4 pathway in renal cell carcinoma.OncoTargets and therapy · 2018Article
- Developing and characterization of single chain variable fragment (scFv) antibody against frizzled 7 (Fzd7) receptor.Bioengineered · 2017Article
- The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia.Molecular cancer · 2017Article
- Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFScientific reports · 2017Article
- Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling.Oncotarget · 2015Review
- SOX4 expression is associated with treatment failure and chemoradioresistance in oral squamous cell carcinoma.BMC cancer · 2015Article
- MicroRNA-132 inhibits cell growth and metastasis in osteosarcoma cell lines possibly by targeting Sox4.International journal of oncology · 2015Article
- Bioinformatics analyses of significant prognostic risk markers for thyroid papillary carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Hepatitis B virus replication and sex-determining region Y box 4 production are tightly controlled by a novel positive feedback mechanism.Scientific reports · 2015Article
- Increased expression of SOX4 is a biomarker for malignant status and poor prognosis in patients with non-small cell lung cancer.Molecular and cellular biochemistry · 2015Article
- Sox4 Expression Confers Bladder Cancer Stem Cell Properties and Predicts for Poor Patient Outcome.International journal of biological sciences · 2015Article
- SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis.BMC neurology · 2014Article
- SOX4 expression is closely associated with differentiation and lymph node metastasis in oral squamous cell carcinoma.Medical molecular morphology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microarray RNA gene expression profiling analysis has shown that Sox4 (Sry-related high mobility group (HMG) box 4) is one of the most upregulated genes in adenoid cystic carcinoma (ACC), relative to non-neoplastic tissue of origin. Here, we show that Sox4 protein is similarly upregulated in ACC by immunohistochemistry of 28 primary cancers and 20 normal tissues. To elucidate the functional significance of these findings, RNA interference (RNAi)-mediated RNA silencing was used to downregulate Sox4 expression in the ACC-derived cell line, ACC3. With confirmed knockdown of Sox4 protein, cell viability was reduced by 51%, with a corresponding increase of apoptosis to 85% as compared to 12% in controls. Apoptosis was confirmed by cell morphology, DNA fragmentation and flow cytometry. Cells could be rescued from the proapoptotic effects of Sox4 RNAi by co-transfection with a construct expressing functional Sox4. Microarray gene expression profiling of RNAi knockdown experiments shows that downregulation of Sox4-modulated expression of critical genes involved in apoptosis and cell cycle control. Overall, our findings suggest that Sox4 contributes to the malignant phenotype of ACC cells by promoting cell survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.