ArticleProceedings of the National Academy of Sciences of the United States of America2006
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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Who cites it
73 citing papers in PubMed, 150 citations in OpenAlex.
- Predictable clonal hierarchies from restricted progenitors provide a framework for cell type-specific therapies in glioblastoma.bioRxiv : the preprint server for biology · 2026Article
- Sweet Aging: Glycocalyx and Galectins in CNS Aging and Neurodegenerative Disorders.International journal of molecular sciences · 2025Review
- Secretome of the Olfactory Ensheathing Cells Influences the Behavior of Neural Stem Cells.International journal of molecular sciences · 2024Article
- Development and Characterization of Bioinspired Lipid Raft Nanovesicles for Therapeutic Applications.ACS applied materials & interfaces · 2022Article
- Single-cell RNA sequencing reveals NestinScience China. Life sciences · 2022Article
- Galectin-1 Contributes to Vascular Remodeling and Blood Flow Recovery After Cerebral Ischemia in Mice.Translational stroke research · 2022Article
- Galectin-1 and -3 in high amounts inhibit angiogenic properties of human retinal microvascular endothelial cells in vitro.PloS one · 2022Article
- Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma.International journal of molecular sciences · 2021Review
- Review
- Galectins - Important players of the immune response to CNS parasitic infection.Brain, behavior, & immunity - health · 2021Review
- Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions.Frontiers in neuroanatomy · 2021Review
- The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles.Frontiers in neurology · 2021Article
- The Emerging Role of Galectins andCells · 2020Review
- Animal Galectins and Plant Lectins as Tools for Studies in Neurosciences.Current neuropharmacology · 2020Review
- Extracellular Vesicles as a Potential Therapy for Neonatal Conditions: State of the Art and Challenges in Clinical Translation.Pharmaceutics · 2019Review
- Role of macrophages in peripheral nerve injury and repair.Neural regeneration research · 2019Review
- Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals.Journal of neurovirology · 2019Article
- Neural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche.Frontiers in cell and developmental biology · 2019Review
- Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury.Tissue engineering. Part A · 2018Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the NSCs. Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.