ArticleThe Journal of general physiology2006
Feedback network controls photoreceptor output at the layer of first visual synapses in Drosophila.
Article in The Journal of general physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
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- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
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- Binocular mirror-symmetric microsaccadic sampling enablesProceedings of the National Academy of Sciences of the United States of America · 2022Article
- High-speed imaging of light-induced photoreceptor microsaccades in compound eyes.Communications biology · 2022Article
- Predicting individual neuron responses with anatomically constrained task optimization.Current biology : CB · 2021Article
- Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Acute Application of Imidacloprid Alters the Sensitivity of Direction Selective Motion Detecting Neurons in an Insect Pollinator.Frontiers in physiology · 2021Article
- The spectral sensitivity of Drosophila photoreceptors.Scientific reports · 2020Article
- Serotonergic modulation of visual neurons in Drosophila melanogaster.PLoS genetics · 2020Article
- Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Sparse identification of contrast gain control in the fruit fly photoreceptor and amacrine cell layer.Journal of mathematical neuroscience · 2020Article
- A minimal synaptic model for direction selective neurons in Drosophila.Journal of vision · 2020Article
- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
- Communication Among Photoreceptors and the Central Clock Affects Sleep Profile.Frontiers in physiology · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
At the layer of first visual synapses, information from photoreceptors is processed and transmitted towards the brain. In fly compound eye, output from photoreceptors (R1-R6) that share the same visual field is pooled and transmitted via histaminergic synapses to two classes of interneuron, large monopolar cells (LMCs) and amacrine cells (ACs). The interneurons also feed back to photoreceptor terminals via numerous ligand-gated synapses, yet the significance of these connections has remained a mystery. We investigated the role of feedback synapses by comparing intracellular responses of photoreceptors and LMCs in wild-type Drosophila and in synaptic mutants, to light and current pulses and to naturalistic light stimuli. The recordings were further subjected to rigorous statistical and information-theoretical analysis. We show that the feedback synapses form a negative feedback loop that controls the speed and amplitude of photoreceptor responses and hence the quality of the transmitted signals. These results highlight the benefits of feedback synapses for neural information processing, and suggest that similar coding strategies could be used in other nervous systems.
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