ReviewThe Journal of cell biology2006
CAR-1 and trailer hitch: driving mRNP granule function at the ER?
Review in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis.EMBO reports · 2025Article
- The role of ER exit sites in maintaining P-body organization and transmitting ER stress response duringbioRxiv : the preprint server for biology · 2024Article
- Involvement of RNA granule proteins in meiotic silencing by unpaired DNA.G3 (Bethesda, Md.) · 2021Article
- Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum.Genes & development · 2020Article
- Emerging Roles of LSM Complexes in Posttranscriptional Regulation of Plant Response to Abiotic Stress.Frontiers in plant science · 2019Review
- Control of tissue size and development by a regulatory element in theAmerican journal of cancer research · 2017Article
- Genome-wide analysis of mRNAs associated with mouse peroxisomes.BMC genomics · 2016Article
- RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line.G3 (Bethesda, Md.) · 2016Article
- Synthetic RNA-protein modules integrated with native translation mechanisms to control gene expression in malaria parasites.Nature communications · 2016Article
- The role of disordered protein regions in the assembly of decapping complexes and RNP granules.Genes & development · 2013Review
- Arabidopsis thaliana LSM proteins function in mRNA splicing and degradation.Nucleic acids research · 2013Article
- HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.The Journal of cell biology · 2012Article
- The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.The EMBO journal · 2012Article
- New insights into the regulation of RNP granule assembly in oocytes.International review of cell and molecular biology · 2012Review
- Multiple means to the same end: the genetic basis of acquired stress resistance in yeast.PLoS genetics · 2011Article
- Translational control of TOP2A influences doxorubicin efficacy.Molecular and cellular biology · 2011Article
- Assembly of RNP granules in stressed and aging oocytes requires nucleoporins and is coordinated with nuclear membrane blebbing.Developmental biology · 2011Article
- Defects in the secretory pathway and high Ca2+ induce multiple P-bodies.Molecular biology of the cell · 2010Article
- Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?Nature reviews. Neuroscience · 2009Review
- Dynamic organization and plasticity of sponge bodies.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The targeting of messenger RNAs (mRNAs) to specific subcellular sites for local translation plays an important role in diverse cellular and developmental processes in eukaryotes, including axis formation, cell fate determination, spindle pole regulation, cell motility, and neuronal synaptic plasticity. Recently, a new conserved class of Lsm proteins, the Scd6 family, has been implicated in controlling mRNA function. Depletion or mutation of members of the Scd6 family, Caenorhabditis elegans CAR-1 and Drosophila melanogaster trailer hitch, lead to a variety of developmental phenotypes, which in some cases can be linked to alterations in the endoplasmic reticulum (ER). Scd6/Lsm proteins are RNA binding proteins and are found in RNP complexes associated with translational control of mRNAs, and these complexes can colocalize with the ER. These findings raise the possibility that localization and translational regulation of mRNAs at the ER plays a role in controlling the organization of this organelle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.