ArticleThe Journal of experimental medicine2006
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 132 citations in OpenAlex.
- T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children.Malaria journal · 2013Trial
- Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.Immunity, inflammation and disease · 2025Review
- Malaria and dyserythropoiesis: a mini review.Frontiers in cellular and infection microbiology · 2025Review
- Immune Mechanisms in Inflammatory Anemia.Annual review of immunology · 2023Review
- Erythropoiesis and Malaria, a Multifaceted Interplay.International journal of molecular sciences · 2022Review
- Review
- The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm.Frontiers in immunology · 2022Review
- Macrophage migration inhibitory factor contributes to immunopathogenesis duringFrontiers in cellular and infection microbiology · 2022Article
- Macrophage migration inhibitory factor in Nodding syndrome.PLoS neglected tropical diseases · 2021Article
- Predictors of outcome in childhoodVirulence · 2020Review
- Role of Host and Parasite MIF Cytokines duringTropical medicine and infectious disease · 2020Review
- The immunobiology of MIF: function, genetics and prospects for precision medicine.Nature reviews. Rheumatology · 2019Review
- Low expressionCytokine: X · 2019Article
- Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Potential of Vitamin E Deficiency, Induced by Inhibition of α-Tocopherol Efflux, in Murine Malaria Infection.International journal of molecular sciences · 2018Review
- Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy.The Journal of clinical investigation · 2018Article
- Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection.Nature communications · 2018Article
- A brief review on features of falciparum malaria during pregnancy.Journal of public health in Africa · 2017Article
- Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model.Scientific reports · 2017Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedA critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia.2015 · Shanmugasundaram, Ganapathy [Corrected to Ganapathy-Kanniappan, Shanmugasundaram]
Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
Abstract
The pathogenesis of malarial anemia is multifactorial, and the mechanisms responsible for its high mortality are poorly understood. Studies indicate that host mediators produced during malaria infection may suppress erythroid progenitor development (Miller, K.L., J.C. Schooley, K.L. Smith, B. Kullgren, L.J. Mahlmann, and P.H. Silverman. 1989. Exp. Hematol. 17:379-385; Yap, G.S., and M.M. Stevenson. 1991. Ann. NY Acad. Sci. 628:279-281). We describe an intrinsic role for macrophage migration inhibitory factor (MIF) in the development of the anemic complications and bone marrow suppression that are associated with malaria infection. At concentrations found in the circulation of malaria-infected patients, MIF suppressed erythropoietin-dependent erythroid colony formation. MIF synergized with tumor necrosis factor and gamma interferon, which are known antagonists of hematopoiesis, even when these cytokines were present in subinhibitory concentrations. MIF inhibited erythroid differentiation and hemoglobin production, and it antagonized the pattern of mitogen-activated protein kinase phosphorylation that normally occurs during erythroid progenitor differentiation. Infection of MIF knockout mice with Plasmodium chabaudi resulted in less severe anemia, improved erythroid progenitor development, and increased survival compared with wild-type controls. We also found that human mononuclear cells carrying highly expressed MIF alleles produced more MIF when stimulated with the malarial product hemozoin compared with cells carrying low expression MIF alleles. These data suggest that polymorphisms at the MIF locus may influence the levels of MIF produced in the innate response to malaria infection and the likelihood of anemic complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.