ArticleCellular and molecular neurobiology2006
Glutamate uptake is stimulated by extracellular S100B in hippocampal astrocytes.
Article in Cellular and molecular neurobiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Monosodium Glutamate Treatment Elevates the Immunoreactivity of GFAP and S100β in Caudate Nucleus of the Striatum in Rats.Biomedicines · 2024Article
- Exploring molecular mechanisms of postoperative delirium through multi-omics strategies in plasma exosomes.Scientific reports · 2024Article
- m6A methylation: Critical roles in aging and neurological diseases.Frontiers in molecular neuroscience · 2023Review
- Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.Molecular therapy. Nucleic acids · 2022Article
- Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes.Aging · 2020Article
- Dual Functions of Microglia in Ischemic Stroke.Neuroscience bulletin · 2019Review
- The blood brain barrier: Insights from development and ageing.Tissue barriers · 2017Review
- Astrocyte Dysfunction Induced by Alcohol in Females but Not Males.Brain pathology (Zurich, Switzerland) · 2016Article
- Re-exposure to the hypobaric hypoxic brain injury of high altitude: plasma S100B levels and the possible effect of acclimatisation on blood-brain barrier dysfunction.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle.Frontiers in aging neuroscience · 2016Review
- Serum S100B Protein is Specifically Related to White Matter Changes in Schizophrenia.Frontiers in cellular neuroscience · 2016Article
- Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease.Current medicinal chemistry · 2016Review
- Changes in Astroglial Markers in a Maternal Immune Activation Model of Schizophrenia in Wistar Rats are Dependent on Sex.Frontiers in cellular neuroscience · 2015Article
- Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus.BioMed research international · 2015Article
- Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns.The Journal of comparative neurology · 2013Article
- High-glucose and S100B stimulate glutamate uptake in C6 glioma cells.Neurochemical research · 2012Article
- PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation.Journal of neuroinflammation · 2010Article
- S100B Protein, A Damage-Associated Molecular Pattern Protein in the Brain and Heart, and Beyond.Cardiovascular psychiatry and neurology · 2010Article
- S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance.Cardiovascular psychiatry and neurology · 2010Article
- Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1.S100B is a calcium-binding protein expressed and secreted by astrocytes, which has been implicated in glial-neuronal communication. Extracellular S100B appears to protect hippocampal neurons against toxic concentrations of glutamate. Here we investigated a possible autocrine role of S100B in glutamate uptake activity. 2. Astrocyte cultures were prepared of hippocampi from neonate Wistar rats. [(3)H] Glutamate uptake was measured after addition of S100B protein, antibody anti-S100B or TRTK-12, a peptide that blocks S100B activity mediated by the C-terminal region. 3.Antibody anti-S100B addition decreased glutamate uptake measured 30 min after medium replacement, without affecting cell integrity or viability. Moreover, low levels of S100B (less than 0.1 ng/mL) stimulated glutamate uptake measured immediately after medium replacement. 4. This finding reinforces the importance of astrocytes in the glutamatergic transmission, particularly the role of S100B neuroprotection against excitotoxic damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.