ArticleMolecular and cellular biochemistry2006
Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 89 citations in OpenAlex.
- Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Clinical interventions in aging · 2019Trial
- Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial.The American journal of clinical nutrition · 2013Trial
- Wound-Healing and Antibacterial Activities ofJournal of microbiology and biotechnology · 2026Article
- Sea Buckthorn (Foods (Basel, Switzerland) · 2026Review
- The role of sea buckthorn in skin and mucosal health: a review from an anti-inflammatory perspective.Frontiers in pharmacology · 2025Review
- Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2.Archives of pharmacal research · 2023Article
- Chemosensitization Effect of Seabuckthorn (Foods (Basel, Switzerland) · 2022Article
- Exploratory study of sea buckthorn enhancing QiangGuYin efficacy by inhibiting CKIP-1 and Notum activating the Wnt/β-catenin signaling pathway and analysis of active ingredients by molecular docking.Frontiers in pharmacology · 2022Article
- Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties.Frontiers in pharmacology · 2022Review
- Antibacterial and Therapeutic Potentials of theBioMed research international · 2021Article
- Article
- Cross-Linked Microencapsulation of COMolecules (Basel, Switzerland) · 2020Article
- RETRACTED: Involvement of NF-κB in the reversal of CYP3A down-regulation induced by sea buckthorn in BCG-induced rats.PloS one · 2020Article
- Adjuvant activity of ethanol extract of Hippophae rhamnoides leaves with inactivated rabies virus antigen.Pharmaceutical biology · 2018Article
- Abundance of active ingredients in sea-buckthorn oil.Lipids in health and disease · 2017Review
- From Inflammation to Current and Alternative Therapies Involved in Wound Healing.International journal of inflammation · 2017Review
- Traditional Therapies for Skin Wound Healing.Advances in wound care · 2016Review
- Antimicrobial and in vitro wound healing properties of novel clay based bionanocomposite films.Journal of materials science. Materials in medicine · 2014Article
- Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed.PloS one · 2012Article
- Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn).ISRN pharmacology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present investigation was undertaken to determine the efficacy of topical administration of flavone of sea buckthorn (Hippophae rhamnoides L.) on cutaneous wound healing in rats. Four full-thickness excision wounds were created on the back of rat and 1.0% w/v flavone prepared in propylene glycol was applied topically. Control animals received the vehicle alone in an identical manner. The healing of the wound was assessed by the rate of wound contraction, period of epithelialization, hydroxyproline, hexosamine, antioxidants estimation and histopathology of the granulation tissue. The sea buckthorn flavone promoted the wound healing activity as indicated by improved rate of wound contraction, decreased time taken for epithelialization (16.3 days versus 24.8 days in controls) and significant increase in hydroxyproline (26.0%) and hexosamine (30.0%) content. These findings were also confirmed by histopathological examinations. In addition, it was observed that sea buckthorn flavone possesses potent antioxidant properties as evidenced by significant increase in reduced glutathione (55.0%), vitamin C (70.0%) and catalase (20.0%) activities in wound granulation tissue. The flavone treatment also resulted in significant decrease in lipid peroxide levels (39.0%). The results suggest that the sea buckthorn flavone promotes wound healing activity.
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