ArticleBritish journal of pharmacology2006
Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 102 citations in OpenAlex.
- Positive Effects of a Lecithin-Based Delivery Form ofNutrients · 2022Trial
- Unravelling the synergistic potential of Olibanum extract and Bacillus clausii in combating intestinal cryptosporidiosis in immunosuppressed mice.PLoS neglected tropical diseases · 2026Article
- Article
- The Efficacy of Ayurvedic Herbs in the Prevention and Treatment of Inflammatory Bowel Disease: A Scoping Review.Cureus · 2025Review
- The journey of boswellic acids from synthesis to pharmacological activities.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Possible role of frankincense in the treatment of benign essential blepharospasm.American journal of ophthalmology case reports · 2023Article
- Effects of Frankincense Compounds on Infection, Inflammation, and Oral Health.Molecules (Basel, Switzerland) · 2022Review
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- Biological and computational studies provide insights intoBiochemistry and biophysics reports · 2021Article
- Antidiarrheal Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The Effect of Beta-Boswellic Acid on the Expression ofAdvanced pharmaceutical bulletin · 2020Article
- Toxicological and Pharmacological Activities ofFrontiers in pharmacology · 2020Article
- Traditional Persian topical medications for gastrointestinal diseases.Iranian journal of basic medical sciences · 2017Review
- Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation.World journal of gastroenterology · 2017Article
- Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities.International journal of molecular sciences · 2016Article
- Simultaneous quantification of triterpenoic acids by high performance liquid chromatography method in the extracts of gum resin of Boswellia serrata obtained by different extraction techniques.Chemistry Central journal · 2016Article
- A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis.Clinical, cosmetic and investigational dermatology · 2014Article
- Article
- Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.British journal of pharmacology · 2012Article
- The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys.Jundishapur journal of natural pharmaceutical products · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride. The inhibitory effect of BSE on acetylcholine-induced contractions was reduced by the L-type Ca(2+) channel blockers verapamil and nifedipine, but not by the sarcoplasmic reticulum Ca(2+)-ATPase inhibitor cyclopiazonic acid, by the phosphodiesterase type IV inhibitor rolipram or by the lipoxygenase inhibitor zileuton. 3-acetyl-11-keto-beta-boswellic acid, one of the main active ingredients of B. serrata, inhibited acetylcholine-induced contractions. BSE inhibited upper gastrointestinal transit in croton oil-treated mice as well as castor oil-induced diarrhoea. However, BSE did not affect intestinal motility in control mice, both in the small and in the large intestine. It is concluded that BSE directly inhibits intestinal motility with a mechanism involving L-type Ca(2+) channels. BSE prevents diarrhoea and normalizes intestinal motility in pathophysiological states without slowing the rate of transit in control animals. These results could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease.
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