ReviewArchives of disease in childhood. Fetal and neonatal edition2006
Which inotrope for which baby?
Review in Archives of disease in childhood. Fetal and neonatal edition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine.Critical care medicine · 2009Guideline
- Use of antihypotensive therapies in extremely preterm infants.Pediatrics · 2013Trial
- Cardiorespiratory effects of changes in end expiratory pressure in ventilated newborns.Archives of disease in childhood. Fetal and neonatal edition · 2007Trial
- Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model.Scientific reports · 2026Article
- Pulmonary Peak Flow Assessment: An Easy Tool for Cardiac Output Estimation in Hemodynamically Stable Neonates.International journal of pediatrics · 2026Article
- Tachycardia and persistent pulmonary hypertension of the newborn.Frontiers in pediatrics · 2025Article
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- A survey on management practices of hypotension in preterm neonates: an Indian perspective.Frontiers in pediatrics · 2024Article
- The effect of norepinephrine on clinical and hemodynamic parameters in neonates with shock: a retrospective cohort study.European journal of pediatrics · 2022Article
- Neonatologist Performed Echocardiography for Evaluating the Newborn Infant.Frontiers in pediatrics · 2022Review
- Utility of Low Dose Vasopressin for Persistent Pulmonary Hypertension of Newborn with Catecholamine Refractory Shock.Indian journal of pediatrics · 2021Article
- Effect of Fluid Bolus on Clinical Outcomes in Very Low Birth Weight Infants.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Management of Multi Organ Dysfunction in Neonatal Encephalopathy.Frontiers in pediatrics · 2020Review
- Does Levetiracetam Administration Prevent Cardiac Damage in Adulthood Rats Following Neonatal Hypoxia/Ischemia-Induced Brain Injury?Medicina (Kaunas, Lithuania) · 2018Article
- Cardiovascular Supportive Therapies for Neonates With Asphyxia - A Literature Review of Pre-clinical and Clinical Studies.Frontiers in pediatrics · 2018Review
- Echocardiographic Evaluation of Ventricular Function-For the Neonatologist and Pediatric Intensivist.Frontiers in pediatrics · 2018Review
- Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence.World journal of clinical pediatrics · 2016Article
- Management of Shock in Neonates.Indian journal of pediatrics · 2015Review
- Cardiac troponin I concentrations as a marker of neurodevelopmental outcome at 18 months in newborns with perinatal asphyxia.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Determinants of neonatal blood pressure.Current hypertension reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While we know a lot about blood pressure (BP) responses to various inotropes and a bit about systemic and organ blood flow responses, we know almost nothing about how different inotropes affect clinical outcomes. Low systemic blood flow (SBF) is common in the first 24 h after birth in very preterm babies (and more mature babies with severe respiratory problems) and is not always reflected by low BP. The causes of this low SBF are complex but may relate to maladaptation to high extrauterine systemic (and sometimes pulmonary) vascular resistance. After day 1, hypotensive babies are more likely to have normal or high SBF reflecting vasodilatation. Empirically, inotropes that reduce afterload (such as dobutamine) may be more appropriate in the transitional period, while those with more vasoconstrictor actions (such as dopamine) may be more appropriate later on. Defining the haemodynamic in an individual baby needs both BP and echocardiographic measures of SBF. Research in this area needs to move beyond just demonstrating changes in physiological variables to showing improvements in important clinical outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.